Treatment of Focal Brain Ischemia with Viral Vector-Mediated Gene Transfer

2010 ◽  
pp. 429-446 ◽  
Author(s):  
Hua Su ◽  
Guo-Yuan Yang
Keyword(s):  
Gene Transfer ◽  
Brain Ischemia ◽  
Viral Vector ◽  
Focal Brain Ischemia

Midkine gene transfer protects against focal brain ischemia and augments neurogenesis

2009 ◽  
Vol 285 (1-2) ◽  
pp. 78-84 ◽  
Author(s):  
Eiichi Ishikawa ◽  
Hiroaki Ooboshi ◽  
Yasuhiro Kumai ◽  
Junnichi Takada ◽  
Kuniyuki Nakamura ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Brain Ischemia ◽  
Focal Brain Ischemia

scholarly journals Anti—Monocyte Chemoattractant Protein-1 Gene Therapy Protects against Focal Brain Ischemia in Hypertensive Rats

2004 ◽  
Vol 24 (12) ◽  
pp. 1359-1368 ◽  
Author(s):  
Yasuhiro Kumai ◽  
Hiroaki Ooboshi ◽  
Junichi Takada ◽  
Masahiro Kamouchi ◽  
Takanari Kitazono ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Brain Ischemia ◽  
Infarct Volume ◽  
Dominant Negative ◽  
Hypertensive Rats ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Focal Brain Ischemia

Monocyte chemoattractant protein-1 (MCP-1) is expressed in the ischemic cortex after focal brain ischemia and appears to exacerbate ischemic damage. The authors examined the effect of gene transfer of dominant negative MCP-1, called 7ND, 90 minutes after induction of focal brain ischemia in hypertensive rats. Adenoviral vectors encoding mutant MCP-1 (Ad7ND; n = 11), or Escherichia coli β-galactosidase (AdlacZ; n = 17) as control were injected into the lateral ventricle of male spontaneously hypertensive rats. Both AdlacZ (n = 12) and Ad7ND (n = 6) administration provided transgene expression as early as 6 hours after injection and the expression further increased on day 1, followed by a sustained detection on day 5. Five days after ischemia, infarct volume (75 ± 13 mm3, n = 5, mean ± SD) significantly reduced to 72% of control (104 ± 22 mm3, n = 5, P < 0.05) by 7ND gene transfer. Numbers of leukocytes in the vessels (48.3 ± 32.9/cm2) and macrophage/monocyte infiltration (475.2 ± 125.5 /mm2) of the infarct area in the Ad7ND group were significantly less than those measured in the AdlacZ group (143.8 ± 72.1/cm2 and 671.8 ± 125.5/mm2, P < 0.05, respectively). In summary, the postischemic gene transfer of dominant negative MCP-1 attenuated the infarct volume and infiltration of inflammatory cells, suggesting potential usefulness of the anti–MCP-1 gene therapy.

scholarly journals Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia

Gene Therapy ◽  
2005 ◽  
Vol 12 (6) ◽  
pp. 487-493 ◽  
Author(s):  
J Takada ◽  
H Ooboshi ◽  
T Ago ◽  
T Kitazono ◽  
H Yao ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Brain Ischemia ◽  
Neurotrophic Factor ◽  
Focal Brain Ischemia

Post-ischemic gene transfer of IL-10 protects against global brain ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S507-S507 ◽  
Author(s):  
Takashi Shichita ◽  
Hiroaki Ooboshi ◽  
Yasuhiro Kumai ◽  
Masahiro Kumai ◽  
Junichi Takada ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Brain Ischemia ◽  
Global Brain Ischemia ◽  
Global Brain

scholarly journals Sodium time course using23Na MRI in reversible focal brain ischemia in the monkey

2009 ◽  
Vol 30 (1) ◽  
pp. 219-223 ◽  
Author(s):  
George C. LaVerde ◽  
Charles A. Jungreis ◽  
Edwin Nemoto ◽  
Fernando E. Boada
Keyword(s):  
Brain Ischemia ◽  
Time Course ◽  
Focal Brain Ischemia

Production of Transgenic Farm Animals by Viral Vector-Mediated Gene Transfer

2008 ◽  
Vol 43 ◽  
pp. 355-358 ◽  
Author(s):  
CBA Whitelaw ◽  
SG Lillico ◽  
T King
Keyword(s):  
Gene Transfer ◽  
Viral Vector ◽  
Farm Animals

Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia

2007 ◽  
Vol 1153 ◽  
pp. 58-67 ◽  
Author(s):  
Slavianka Georgieva Moyanova ◽  
Lidia Vasileva Kortenska ◽  
Rumiana Gesheva Mitreva ◽  
Vyara Dincova Pashova ◽  
Richard Teke Ngomba ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Mk 801 ◽  
Endothelin 1 ◽  
Multimodal Assessment ◽  
Focal Brain Ischemia

scholarly journals Correction to: Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats

2018 ◽  
Vol 224 (2) ◽  
pp. 739-740 ◽  
Author(s):  
Shotaro Otsuka ◽  
Harutoshi Sakakima ◽  
Takuto Terashi ◽  
Seiya Takada ◽  
Kazuki Nakanishi ◽  
...  
Keyword(s):  
Brain Damage ◽  
Brain Ischemia ◽  
Neuronal Apoptosis ◽  
Focal Brain Ischemia
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