scholarly journals A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH

2009 ◽  
Vol 1250 ◽  
pp. 130-140 ◽  
Author(s):  
Miroslava Macova ◽  
Jaroslav Pavel ◽  
Juan M. Saavedra
Keyword(s):  
Angiotensin Ii ◽  
Tyrosine Hydroxylase ◽  
At1 Receptors ◽  
Brain Tyrosine Hydroxylase

Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis

1995 ◽  
Vol 268 (6) ◽  
pp. R1401-R1405 ◽  
Author(s):  
M. el Ghissassi ◽  
S. N. Thornton ◽  
S. Nicolaidis
Keyword(s):  
Angiotensin Ii ◽  
Salt Intake ◽  
High Sensitivity ◽  
Ang Ii ◽  
Nacl Solution ◽  
At1 Receptors ◽  
Sodium Appetite ◽  
Specific Antagonist

The angiotensin receptor specificity, with respect to fluid intake, of the organum cavum prelamina terminalis (OCPLT), a recently discovered discrete forebrain structure with high sensitivity to angiotensin II (ANG II), was investigated. ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution. Losartan, an ANG II type 1 (AT1) receptor-specific antagonist, produced dose-related (1-100 ng) inhibition of ANG II-induced drinking. The ANG II type 2 receptor-specific antagonist CGP-42112A was ineffective. Intake of the 3% NaCl solution in response to microinjection of either of the antagonists into the OCPLT was never observed. These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.

Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice

2015 ◽  
Vol 99 ◽  
pp. 221-231 ◽  
Author(s):  
Wataru Nemoto ◽  
Yoshiki Ogata ◽  
Osamu Nakagawasai ◽  
Fukie Yaoita ◽  
Takeshi Tadano ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
P38 Mapk ◽  
Nociceptive Behavior ◽  
Mapk Activation ◽  
At1 Receptors

Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachlorideintoxicated rats

1983 ◽  
Vol 18 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Nobuyuki Takei ◽  
Akiharu Watanabe ◽  
Tatsuro Sakata ◽  
Shosaku Hayashi ◽  
Takahiro Obata ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity ◽  
Calculated Amount ◽  
Brain Tyrosine Hydroxylase
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