Facilitated diffusion of angiotensin II from perivascular interstitium to AT1 receptors of the arteriole. A regulating step in vasoconstriction

2011 ◽  
Vol 29 (5) ◽  
pp. 906-914 ◽  
Author(s):  
Maarten ADH Schalekamp ◽  
AH Jan Danser
Keyword(s):  
Angiotensin Ii ◽  
Facilitated Diffusion ◽  
At1 Receptors

Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis

1995 ◽  
Vol 268 (6) ◽  
pp. R1401-R1405 ◽  
Author(s):  
M. el Ghissassi ◽  
S. N. Thornton ◽  
S. Nicolaidis
Keyword(s):  
Angiotensin Ii ◽  
Salt Intake ◽  
High Sensitivity ◽  
Ang Ii ◽  
Nacl Solution ◽  
At1 Receptors ◽  
Sodium Appetite ◽  
Specific Antagonist

The angiotensin receptor specificity, with respect to fluid intake, of the organum cavum prelamina terminalis (OCPLT), a recently discovered discrete forebrain structure with high sensitivity to angiotensin II (ANG II), was investigated. ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution. Losartan, an ANG II type 1 (AT1) receptor-specific antagonist, produced dose-related (1-100 ng) inhibition of ANG II-induced drinking. The ANG II type 2 receptor-specific antagonist CGP-42112A was ineffective. Intake of the 3% NaCl solution in response to microinjection of either of the antagonists into the OCPLT was never observed. These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.

Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice

2015 ◽  
Vol 99 ◽  
pp. 221-231 ◽  
Author(s):  
Wataru Nemoto ◽  
Yoshiki Ogata ◽  
Osamu Nakagawasai ◽  
Fukie Yaoita ◽  
Takeshi Tadano ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
P38 Mapk ◽  
Nociceptive Behavior ◽  
Mapk Activation ◽  
At1 Receptors

Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide

1997 ◽  
Vol 273 (3) ◽  
pp. C1040-C1048 ◽  
Author(s):  
M. Zhu ◽  
R. R. Neubig ◽  
S. M. Wade ◽  
P. Posner ◽  
C. H. Gelband ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
At1 Receptor ◽  
Delayed Rectifier ◽  
Cultured Neurons ◽  
Ang Ii ◽  
Cytoplasmic Loop ◽  
At1 Receptors ◽  
The Third ◽  
Intracellular Changes

Angiotensin II (ANG II) inhibits delayed rectifier K+ current (IK) and stimulates total Ca2+ current (ICa) in neurons cocultured from newborn rat hypothalamus and brain stem, effects mediated via ANG II type 1 (AT1) receptors. Here, we identify potential G protein activator regions of the AT1 receptor responsible for initiating the intracellular changes that lead to alterations in these currents. Intracellular application into cultured neurons of a peptide corresponding to the third cytoplasmic loop of the AT1 receptor (AT1a/i3) mimicked the actions of ANG II on IK and ICa, whereas application of a peptide corresponding to the second cytoplasmic loop (AT1a/i2) did not alter these currents. This modulation of IK and ICa by AT1a/i3 involves intracellular messengers (G alpha q, protein kinase C, and intracellular Ca2+) that are identical to those involved in the modulation of IK and ICa following ANG II activation of AT1 receptors. These data provide functional evidence for a role of the third cytoplasmic loop of the AT1 receptor in G protein coupling and subsequent modulation of ion channel effectors.

scholarly journals Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors

1999 ◽  
Vol 126 (4) ◽  
pp. 1057-1065 ◽  
Author(s):  
P M L Vanderheyden ◽  
F L P Fierens ◽  
J P De Backer ◽  
N Fraeyman ◽  
G Vauquelin
Keyword(s):  
Angiotensin Ii ◽  
At1 Receptor ◽  
Receptor Antagonists ◽  
At1 Receptors ◽  
At1 Receptor Antagonists

Reproductive hormones modulate angiotensin II AT1 receptors in the dorsomedial arcuate nucleus of the female rat.

Endocrinology ◽  
1993 ◽  
Vol 133 (2) ◽  
pp. 939-941 ◽  
Author(s):  
A Seltzer ◽  
K Tsutsumi ◽  
K Shigematsu ◽  
J M Saavedra
Keyword(s):  
Angiotensin Ii ◽  
Arcuate Nucleus ◽  
Reproductive Hormones ◽  
Female Rat ◽  
At1 Receptors
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