Behavioral changes with brief exposures to weak magnetic fields patterned to stimulate long-term potentiation

2009 ◽  
Vol 1261 ◽  
pp. 45-53 ◽  
Author(s):  
Quoc Hao Mach ◽  
Michael A. Persinger
eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
David Arkadir ◽  
Angela Radulescu ◽  
Deborah Raymond ◽  
Naomi Lubarr ◽  
Susan B Bressman ◽  
...  

It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.


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