Differential expression of 14-3-3 protein isoforms in developing rat hippocampus, cortex, rostral migratory stream, olfactory bulb, and white matter

2011 ◽  
Vol 1410 ◽  
pp. 1-11 ◽  
Author(s):  
Takahiko Umahara ◽  
Toshiki Uchihara ◽  
Ayako Nakamura ◽  
Toshihiko Iwamoto
Keyword(s):  
White Matter ◽  
Olfactory Bulb ◽  
Differential Expression ◽  
Rostral Migratory Stream ◽  
Protein Isoforms ◽  
Rat Hippocampus ◽  
Developing Rat ◽  
Migratory Stream

scholarly journals p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse

2009 ◽  
Vol 29 (9) ◽  
pp. 2902-2914 ◽  
Author(s):  
X. Li ◽  
X. Tang ◽  
B. Jablonska ◽  
A. Aguirre ◽  
V. Gallo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype

2013 ◽  
Vol 109 (3) ◽  
pp. 867-872 ◽  
Author(s):  
Geeta Sharma
Keyword(s):  
Olfactory Bulb ◽  
Perceptual Learning ◽  
Progenitor Cells ◽  
Glutamate Release ◽  
Brain Regions ◽  
Odor Discrimination ◽  
Rostral Migratory Stream ◽  
Receptor Expression ◽  
Granule Cell Layer ◽  
Migratory Stream

Addition of newly generated neurons into mature neural circuits in the adult CNS responds to changes in neurotransmitter levels and is tightly coupled to the activity of specific brain regions. This postnatal neurogenesis contributes to plasticity of the olfactory bulb and hippocampus and is thought to play a role in learning and memory, context and odor discrimination, as well as perceptual learning. While acetylcholine plays an important role in odor discrimination and perceptual learning, its role in adult neurogenesis in the olfactory bulb has not been elucidated. In this study, I have examined the functional expression of nAChRs in progenitor cells of the rostral migratory stream (RMS) in the adult olfactory bulb of mice. I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Unlike in the hippocampus, the predominant functional nAChRs on progenitor cells are of α3β4 subtype. Interestingly, functional receptor expression is lost once progenitor cells mature, and are incorporated into the granule cell layer. Instead, nAChRs are now expressed on some presynaptic terminals and modulate glutamate release onto granule cells. My results imply that ACh is a part of the permissive niche and likely plays a role in development of progenitor cells.

scholarly journals Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream

2010 ◽  
Vol 393 (4) ◽  
pp. 673-677 ◽  
Author(s):  
Yosuke Akiba ◽  
John W. Cave ◽  
Nami Akiba ◽  
Brett Langley ◽  
Rajiv R. Ratan ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Olfactory Bulb ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb

2008 ◽  
Vol 27 (7) ◽  
pp. 1585-1595 ◽  
Author(s):  
Shin-ichi Murase ◽  
Chunghee Cho ◽  
Judith M. White ◽  
Alan F. Horwitz
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals Doublecortin Expression in the Olfactory Bulb and Rostral Stream in Infantile Rats after Exposure to Neurotoxin

2019 ◽  
Vol 7 (4) ◽  
pp. 50-55
Author(s):  
D. A. Pozhilov ◽  
T. A. Rumyantseva ◽  
V. E. Varentsov ◽  
A. V. Moskalenko
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Numerical Density ◽  
Neuronal Progenitors ◽  
Neurotoxic Effects ◽  
Immature Neurons ◽  
Mature Neurons ◽  
Old Rats ◽  
The Brain ◽  
Migratory Stream

The aim of the study was to investigate changes of neuroblasts’ numeral destiny in rats’ olfactory bulb and rostral migratory stream after neurotoxic action in infant age.Material and methods. The distribution of DCX, a marker of immature neurons, was studied to reveal the dynamics of its expression in the evolutionary period of ontogenesis in olfactory bulbs and rostral migratory stream in 30, 60, 90, and 180-day-old rats. Modeling of neurotoxic effects was carried out by three times injections of capsaicin on the 30–32 day of life in a total dose of 120 mg/kg. The material for the study was sampled on the 15-, 30- and 60th days of the experiment. The marker was detected on parasagittal paraffin sections, taking into account the layers of the olfactory bulb. The numerical density of DCX+ neurons (pcs/mm2) and their part in the total number of cells were determined.Results. The standard age indicators of the numerical density of immature neurons and their share in the cell population, as well as similar indicators for two months after toxic effects, were established. The administration of toxic doses of capsaicin causes a massive death of mature neurons. Compensatory reaction manifested by activation of neurogenesis in the brain stem niches and an increase in the numerical density neuroblasts in the rostral stream.Conclusions. Activation of neurogenesis during neurodegeneration causes an increase in the number of DCX + neuronal progenitors in the olfactory bulb after 30 days after exposure and maintaining high levels until the end of observation.

scholarly journals VEGFR-1 Regulates Adult Olfactory Bulb Neurogenesis and Migration of Neural Progenitors in the Rostral Migratory Stream In Vivo

2009 ◽  
Vol 29 (27) ◽  
pp. 8704-8714 ◽  
Author(s):  
I. M. Wittko ◽  
A. Schanzer ◽  
A. Kuzmichev ◽  
F. T. Schneider ◽  
M. Shibuya ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Neural Progenitors ◽  
And Migration ◽  
Migratory Stream

scholarly journals Newly-generated cells from the rostral migratory stream in the accessory olfactory bulb of the adult rat

Neuroscience ◽  
1997 ◽  
Vol 81 (2) ◽  
pp. 489-502 ◽  
Author(s):  
L Bonfanti ◽  
P Peretto ◽  
A Merighi ◽  
A Fasolo
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Accessory Olfactory Bulb ◽  
Adult Rat ◽  
Migratory Stream
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