scholarly journals VEGFR-1 Regulates Adult Olfactory Bulb Neurogenesis and Migration of Neural Progenitors in the Rostral Migratory Stream In Vivo

2009 ◽  
Vol 29 (27) ◽  
pp. 8704-8714 ◽  
Author(s):  
I. M. Wittko ◽  
A. Schanzer ◽  
A. Kuzmichev ◽  
F. T. Schneider ◽  
M. Shibuya ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Neural Progenitors ◽  
And Migration ◽  
Migratory Stream

scholarly journals Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jui-Chih Chang ◽  
Yi-Chun Chao ◽  
Huei-Shin Chang ◽  
Yu-Ling Wu ◽  
Hui-Ju Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Olfactory Bulb ◽  
Disease Model ◽  
Intranasal Delivery ◽  
The Difference ◽  
And Migration ◽  
6 Hydroxydopamine ◽  
Locomotor Behaviors ◽  
Migratory Stream

AbstractThe feasibility of delivering mitochondria intranasally so as to bypass the blood–brain barrier in treating Parkinson's disease (PD), was evaluated in unilaterally 6-OHDA-lesioned rats. Intranasal infusion of allogeneic mitochondria conjugated with Pep-1 (P-Mito) or unconjugated (Mito) was performed once a week on the ipsilateral sides of lesioned brains for three months. A significant improvement of rotational and locomotor behaviors in PD rats was observed in both mitochondrial groups, compared to sham or Pep-1-only groups. Dopaminergic (DA) neuron survival and recovery > 60% occurred in lesions of the substantia nigra (SN) and striatum in Mito and P-Mito rats. The treatment effect was stronger in the P-Mito group than the Mito group, but the difference was insignificant. This recovery was associated with restoration of mitochondrial function and attenuation of oxidative damage in lesioned SN. Notably, P-Mito suppressed plasma levels of inflammatory cytokines. Mitochondria penetrated the accessory olfactory bulb and doublecortin-positive neurons of the rostral migratory stream (RMS) on the ipsilateral sides of lesions and were expressed in striatal, but not SN DA neurons, of both cerebral hemispheres, evidently via commissural fibers. This study shows promise for intranasal delivery of mitochondria, confirming mitochondrial internalization and migration via RMS neurons in the olfactory bulb for PD therapy.

scholarly journals p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse

2009 ◽  
Vol 29 (9) ◽  
pp. 2902-2914 ◽  
Author(s):  
X. Li ◽  
X. Tang ◽  
B. Jablonska ◽  
A. Aguirre ◽  
V. Gallo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals KCa3.1 Modulates Neuroblast Migration Along the Rostral Migratory Stream (RMS) In Vivo

2013 ◽  
Vol 24 (9) ◽  
pp. 2388-2400 ◽  
Author(s):  
Kathryn L. Turner ◽  
Harald Sontheimer
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype

2013 ◽  
Vol 109 (3) ◽  
pp. 867-872 ◽  
Author(s):  
Geeta Sharma
Keyword(s):  
Olfactory Bulb ◽  
Perceptual Learning ◽  
Progenitor Cells ◽  
Glutamate Release ◽  
Brain Regions ◽  
Odor Discrimination ◽  
Rostral Migratory Stream ◽  
Receptor Expression ◽  
Granule Cell Layer ◽  
Migratory Stream

Addition of newly generated neurons into mature neural circuits in the adult CNS responds to changes in neurotransmitter levels and is tightly coupled to the activity of specific brain regions. This postnatal neurogenesis contributes to plasticity of the olfactory bulb and hippocampus and is thought to play a role in learning and memory, context and odor discrimination, as well as perceptual learning. While acetylcholine plays an important role in odor discrimination and perceptual learning, its role in adult neurogenesis in the olfactory bulb has not been elucidated. In this study, I have examined the functional expression of nAChRs in progenitor cells of the rostral migratory stream (RMS) in the adult olfactory bulb of mice. I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Unlike in the hippocampus, the predominant functional nAChRs on progenitor cells are of α3β4 subtype. Interestingly, functional receptor expression is lost once progenitor cells mature, and are incorporated into the granule cell layer. Instead, nAChRs are now expressed on some presynaptic terminals and modulate glutamate release onto granule cells. My results imply that ACh is a part of the permissive niche and likely plays a role in development of progenitor cells.

Differential expression of 14-3-3 protein isoforms in developing rat hippocampus, cortex, rostral migratory stream, olfactory bulb, and white matter

2011 ◽  
Vol 1410 ◽  
pp. 1-11 ◽  
Author(s):  
Takahiko Umahara ◽  
Toshiki Uchihara ◽  
Ayako Nakamura ◽  
Toshihiko Iwamoto
Keyword(s):  
White Matter ◽  
Olfactory Bulb ◽  
Differential Expression ◽  
Rostral Migratory Stream ◽  
Protein Isoforms ◽  
Rat Hippocampus ◽  
Developing Rat ◽  
Migratory Stream

scholarly journals Age-dependent visualization of neural progenitor cells within the rostral migratory stream via MRI and endogenously labeled micron-sized iron oxide particles

2018 ◽  
Author(s):  
Dorela D. Shuboni-Mulligan ◽  
Shatadru Chakravarty ◽  
Christiane L. Mallett ◽  
Alexander M. Wolf ◽  
Stacey Forton ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Ex Vivo ◽  
Neural Progenitor ◽  
Rostral Migratory Stream ◽  
Iron Oxide Particles ◽  
The Impact ◽  
Migratory Stream

AbstractThe subventricular zone (SVZ) is one of the primary sources for rodent neural progenitor cells (NPC), however, aging greatly impacts the substructure of the region and rate of new cell birth. To determine if age impacts the rate of in vivo migration within animals, we examined the rostral migratory stream (RMS) of animals across 12 days using an established MRI technique. To visualize NPCs, we injected micron sized particles of iron oxide (MPIO) into the lateral ventricle to endogenously label cells within the SVZ, which then appeared as hypo-intensive spots within MR images. Our in vivo MRI data showed that the rate of migration was significantly different between all ages examined, with decreases in the distance traveled as age progressed. The total number of iron oxide labeled cells within the olfactory bulb on day 12, decrease significantly when compared across ages in ex vivo high-resolution scans. We also, for the first time, demonstrated the endogenous labeling of cells within the dentate gyrus (DG) of hippocampus. Here too, there was a significant decrease in the number of labeled cells within the structure across age. Histology of the NPCs verified the decrease in labeling of cells with doublecortin (DCX) as age progressed for both regions. The dramatic reduction of labeling in NPCs within the SVZ and DG observed with MRI, demonstrates the importance of understanding the impact of age on the relationship of NPC and disease.

scholarly journals Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream

2010 ◽  
Vol 393 (4) ◽  
pp. 673-677 ◽  
Author(s):  
Yosuke Akiba ◽  
John W. Cave ◽  
Nami Akiba ◽  
Brett Langley ◽  
Rajiv R. Ratan ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Olfactory Bulb ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Rostral Migratory Stream ◽  
Migratory Stream

The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: In vivo evidence in the adult rat brain

2008 ◽  
Vol 60 (3) ◽  
pp. 289-299 ◽  
Author(s):  
Julieta G. Mendoza-Torreblanca ◽  
Eduardo Martínez-Martínez ◽  
Miguel Tapia-Rodríguez ◽  
Rogelio Ramírez-Hernández ◽  
Gabriel Gutiérrez-Ospina
Keyword(s):  
Rat Brain ◽  
Rostral Migratory Stream ◽  
Neurogenic Niche ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Migratory Stream ◽  
Periglomerular Cells
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