Repetitive transcranial magnetic stimulation of the dorsal anterior cingulate cortex in the treatment of obsessive compulsive disorder: A double blind randomized clinical trial

2019 ◽  
Vol 12 (2) ◽  
pp. 472
Author(s):  
S. Dhaliwal ◽  
B. Meek ◽  
M. Modirrousta
Keyword(s):  
Clinical Trial ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Anterior Cingulate ◽  
Obsessive Compulsive ◽  
Dorsal Anterior Cingulate Cortex ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Stimulation Of

Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation

2007 ◽  
Vol 37 (11) ◽  
pp. 1645-1649 ◽  
Author(s):  
PERMINDER S. SACHDEV ◽  
COLLEEN K. LOO ◽  
PHILIP B. MITCHELL ◽  
TARA F. McFARQUHAR ◽  
GIN S. MALHI
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Controlled Study ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Dorsolateral Prefrontal

ABSTRACTBackgroundTo determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study.MethodSubjects with treatment-resistant OCD were randomized to rTMS (n=10) or sham rTMS (n=8) for 10 sessions of daily stimulation over the left dorsolateral prefrontal cortex (DLPFC), with subjects and raters being blind to the treatment. Subjects were offered an open extension of up to 20 sessions of rTMS.ResultsThe two groups did not differ on change in Yale–Brown Obsessive Compulsive Scale (YBOCS) or Maudsley Obsessive-Compulsive Inventory scores over 10 sessions, with or without correction for depression ratings. Over 20 sessions, there was a significant reduction in total YBOCS scores, but not after controlling for depression. rTMS over 20 sessions was well tolerated.ConclusionTwo weeks of rTMS over the left DLPFC is ineffective for treatment-resistant OCD.

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