Agile TMS: A multi-locus system for rapid and automatic spatial targeting and mapping

2021 ◽  
Vol 14 (6) ◽  
pp. 1750
Author(s):  
Jaakko Nieminen ◽  
Heikki Sinisalo ◽  
Victor Souza ◽  
Mikko Malmi ◽  
Mikhail Yuryev ◽  
...  
Keyword(s):  
Spatial Targeting ◽  
Locus System

scholarly journals Actin and Microtubules Differently Contribute to Vacuolar Targeting Specificity during the Export from the ER

Membranes ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 299
Author(s):  
Monica De Caroli ◽  
Fabrizio Barozzi ◽  
Luciana Renna ◽  
Gabriella Piro ◽  
Gian-Pietro Di Sansebastiano
Keyword(s):  
Spatial Targeting ◽  
Traffic Regulation ◽  
Emergent Features ◽  
Vacuolar Sorting ◽  
Er Export ◽  
Golgi Network ◽  
Relationship Of ◽  
The Relationship ◽  
Fine Tune

Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation. Considerable advances have been made in recent years in the comprehension of the relationship between the trans-Golgi network/early endosome (TGN/EE) and cytoskeletons, but studies have mainly focused on the transport to and from the plasma membrane. We address here the relationship of the cytoskeleton with different endoplasmic reticulum (ER) export mechanisms toward vacuoles. These emergent features of the plant endomembrane traffic are explored with an in vivo approach, providing clues on the traffic regulation at different levels beyond known proteins’ functions and interactions. We show how traffic of vacuolar markers, characterized by different vacuolar sorting determinants, diverges at the export from the ER, clearly involving different components of the cytoskeleton.

scholarly journals Improved spatial targeting with directionally segmented deep brain stimulation leads for treating essential tremor

2012 ◽  
Vol 9 (4) ◽  
pp. 046005 ◽  
Author(s):  
Maureen Keane ◽  
Steve Deyo ◽  
Aviva Abosch ◽  
Jawad A Bajwa ◽  
Matthew D Johnson
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Spatial Targeting ◽  
Deep Brain

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy

Nano Letters ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 3822-3829 ◽  
Author(s):  
Song Shen ◽  
Hong-Jun Li ◽  
Kai-Ge Chen ◽  
Yu-Cai Wang ◽  
Xian-Zhu Yang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ph Sensitive ◽  
Tumor Associated Macrophages ◽  
Spatial Targeting

Spatial targeting evaluation of energy and environmental performance of waste-to-energy processing

2018 ◽  
Vol 12 (4) ◽  
pp. 731-744 ◽  
Author(s):  
Petar S. Varbanov ◽  
Timothy G. Walmsley ◽  
Yee V. Fan ◽  
Jiří J. Klemeš ◽  
Simon J. Perry
Keyword(s):  
Environmental Performance ◽  
Waste To Energy ◽  
Spatial Targeting ◽  
Energy Processing

scholarly journals Navigating the Fog: A Correlated XRM and FIB-SEM Imaging Pipeline for the Rapid and Precise Spatial Targeting of Rare Structures in Biological Samples

2018 ◽  
Vol 24 (S1) ◽  
pp. 2312-2313 ◽  
Author(s):  
Matthew S. Joens ◽  
Daniel J. Geanon ◽  
Peter O. Bayguinov ◽  
Kory J. Lavine ◽  
James A.J. Fitzpatrick
Keyword(s):  
Biological Samples ◽  
Spatial Targeting ◽  
Sem Imaging

scholarly journals The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem

2016 ◽  
Author(s):  
Mehdi Maadooliat ◽  
Naveen K. Bansal ◽  
Jiblal Upadhya ◽  
Manzur R. Farazi ◽  
Zhan Ye ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Linkage Disequilibrium ◽  
Fine Mapping ◽  
Disease Model ◽  
Disease Association ◽  
Simple Relationship ◽  
Locus System ◽  
Using Data ◽  
Relationship Of ◽  
The Relationship

AbstractSeveral important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site. A complete description of this two-locus system is of particular importance to experimental efforts to fine map association signals for complex diseases. Here, we present a simple relationship between disease association statistics and the decline of linkage disequilibrium from a causal site. A complete derivation of this relationship from a general disease model is shown for very large sample sizes. Quite interestingly, this relationship holds across all modes of inheritance. Extensive Monte Carlo simulations using a disease genetics model applied to chromosomes subjected to a standard model of recombination are employed to better understand the variation around this fine mapping theorem due to sampling effects. We also use this relationship to provide a framework for estimating properties of a non-interrogated causal site using data at closely linked markers. We anticipate that understanding the patterns of disease association decay with declining linkage disequilibrium from a causal site will enable more powerful fine mapping methods.

scholarly journals A Two-Locus System Controls Susceptibility to Colitis-Associated Colon Cancer in Mice

Oncotarget ◽  
2010 ◽  
Vol 1 (6) ◽  
pp. 436-446 ◽  
Author(s):  
Lauren Van Der Kraak ◽  
Charles Meunier ◽  
Claire Turbide ◽  
Serge Jothy ◽  
Louis Gaboury ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Locus System
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