A new series of water soluble mixed ligand complexes [MII(L)(bpy)AcO].nH2O M = Cu, (n=1) (1); Co (2), Mn (3), Ni (4) (n=4) and Zn (5) (n=2) have been synthesized from 2-(2-Morpholinoethylimino)methyl)phenol Schiff base ligand (HL) and 2,2�-bipyridine in a 1:1:1 molar ratio. The resulting complexes were characterized by spectral techniques. The spectral data of these complexes suggest an octahedral geometry. In vitro antioxidant activity results of DPPH assay, hydroxyl radical, super oxide and nitric oxide for complexes (1-5) were compared with ligand (HL) and in vitro antimicrobial activities of all compounds were examined against selected bacterial and fungal strains which indicate that the complexes exhibit higher antimicrobial activity than free ligand (HL). Gel electrophoresis results indicated that, complexes (1) and (2) have exhibited more DNA cleavage efficiency than others. The intrinsic binding constant (Kb) values for the complexes (1-5) observed by electronic absorption technique were in the order of (1) ] (4) ] (5) ] (2) ] (3) and DNA binding affinity values for these complexes obtained by viscosity measurements were in the order of ethidium bromide ] (1) ] (2) ] (3) ] (4) ] (5).
Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies
