Synthesis, DNA interaction, topoisomerase I, II inhibitory and cytotoxic effects of water soluble silicon (IV) phthalocyanine and napthalocyanines bearing 1-acetylpiperazine units

2019 ◽  
Vol 160 ◽  
pp. 136-144 ◽  
Author(s):  
Hüseyin Baş ◽  
Burak Barut ◽  
Zekeriya Biyiklioglu ◽  
Arzu Özel
Keyword(s):  
Topoisomerase I ◽  
Dna Interaction ◽  
Water Soluble ◽  
Cytotoxic Effects ◽  
Soluble Silicon

Synthesis of water‐soluble BODIPY dyes and investigation of their DNA interaction properties and cytotoxicity/phototoxicity

2021 ◽  
Author(s):  
Turgut Keleş ◽  
Burak Barut ◽  
Sercan Yıldırım ◽  
Can Özgür Yalçın ◽  
Zekeriya Biyiklioglu
Keyword(s):  
Dna Interaction ◽  
Water Soluble

scholarly journals DNA Interaction and Dual Topoisomerase I and II Inhibition Properties of the Anti-Tumor Drug Prodigiosin

2005 ◽  
Vol 85 (2) ◽  
pp. 870-879 ◽  
Author(s):  
Beatriz Montaner ◽  
Wilmar Castillo-Ávila ◽  
Marc Martinell ◽  
Rupert Öllinger ◽  
Joan Aymami ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Interaction

Synthesis of 14-Azacamptothecin, a Water-Soluble Topoisomerase I Poison

2005 ◽  
Vol 7 (5) ◽  
pp. 835-837 ◽  
Author(s):  
Nicolas J. Rahier ◽  
Kejun Cheng ◽  
Rong Gao ◽  
Brian M. Eisenhauer ◽  
Sidney M. Hecht
Keyword(s):  
Topoisomerase I ◽  
Water Soluble

Preparation and oxygen sensing properties of water-soluble silicon nanoparticles assembled SBA-15

2019 ◽  
Vol 111 ◽  
pp. 1-6 ◽  
Author(s):  
Ting Gong ◽  
Yanjuan Li ◽  
Bingfu Lei ◽  
Jianle Zhuang ◽  
Yingliang Liu ◽  
...  
Keyword(s):  
Silicon Nanoparticles ◽  
Oxygen Sensing ◽  
Water Soluble ◽  
Sensing Properties ◽  
Soluble Silicon

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

scholarly journals In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells

Blood ◽  
1995 ◽  
Vol 85 (10) ◽  
pp. 2817-2828 ◽  
Author(s):  
FM Uckun ◽  
CF Stewart ◽  
G Reaman ◽  
LM Chelstrom ◽  
J Jin ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Topoisomerase I ◽  
Drug Exposure ◽  
Lymphoblastic Leukemia ◽  
Severe Combined Immunodeficiency ◽  
Water Soluble ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
B Lineage

Topotecan [(S)-9-dimethylaminomethyl-10-hydroxycamptothecin hydrochloride; SK&F 104864-A, NSC 609699], a water soluble semisynthetic analogue of the alkaloid camptothecin, is a potent topoisomerase I inhibitor. Here we show that topotecan stabilizes topoisomerase I/DNA cleavable complexes in radiation-resistant human B-lineage acute lymphoblastic leukemia (ALL) cells, causes rapid apoptotic cell death despite high-level expression of bcl-2 protein, and inhibits ALL cell in vitro clonogenic growth in a dose-dependent fashion. Furthermore, topotecan elicited potent antileukemic activity in three different severe combined immunodeficiency (SCID) mouse models of human poor prognosis ALL and markedly improved event-free survival of SCID mice challenged with otherwise fatal doses of human leukemia cells at systemic drug exposure levels that can be easily achieved in children with leukemia.

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