Age-dependent effects on biochemical variables and toxicity induced by cyclic peptide toxin microcystin-LR in mice

2005 ◽  
Vol 140 (1) ◽  
pp. 11-19 ◽  
Author(s):  
P.V. Lakshmana Rao ◽  
Nidhi Gupta ◽  
R. Jayaraj ◽  
A.S.B. Bhaskar ◽  
P.C. Jatav
Keyword(s):  
Cyclic Peptide ◽  
Biochemical Variables ◽  
Age Dependent ◽  
Peptide Toxin

Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice

Toxicology ◽  
2003 ◽  
Vol 188 (2-3) ◽  
pp. 285-296 ◽  
Author(s):  
Nidhi Gupta ◽  
S.C. Pant ◽  
R. Vijayaraghavan ◽  
P.V.Lakshmana Rao
Keyword(s):  
Cyclic Peptide ◽  
Toxicity Evaluation ◽  
Comparative Toxicity ◽  
Peptide Toxin

Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR.

1996 ◽  
Vol 62 (11) ◽  
pp. 4086-4094 ◽  
Author(s):  
D G Bourne ◽  
G J Jones ◽  
R L Blakeley ◽  
A Jones ◽  
A P Negri ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Bacterial Degradation ◽  
Peptide Toxin

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin

1989 ◽  
Vol 185 (1) ◽  
pp. 86-100 ◽  
Author(s):  
J.E. Eriksson ◽  
G.I.L. Paatero ◽  
J.A.O. Meriluoto ◽  
G.A. Codd ◽  
G.E.N. Kass ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Peptide Toxin ◽  
Isolated Rat

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

1992 ◽  
Vol 118 (6) ◽  
pp. 420-424 ◽  
Author(s):  
Rie Nishiwaki-Matsushima ◽  
Tetsuya Ohta ◽  
Shinji Nishiwaki ◽  
Masami Suganuma ◽  
Kiyomi Kohyama ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Cyclic Peptide ◽  
Tumor Promotion ◽  
Peptide Toxin

The structure of a cyclic peptide toxin, cyanogenosin-rr from microcystis aeruginosa

1988 ◽  
Vol 29 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Prabha Painuly ◽  
Ricardo Perez ◽  
Toshio Fukai ◽  
Yuzuru Shimizu
Keyword(s):  
Microcystis Aeruginosa ◽  
Cyclic Peptide ◽  
Peptide Toxin

Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin

1990 ◽  
Vol 1025 (1) ◽  
pp. 60-66 ◽  
Author(s):  
John E. Eriksson ◽  
Lotte Grönberg ◽  
Siv Nygård ◽  
J.Peter Slotte ◽  
Jussi A.O. Meriluoto
Keyword(s):  
Cyclic Peptide ◽  
Peptide Toxin

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

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