Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis

2020 ◽  
Author(s):  
Haoran Hong ◽  
Hongyu Wang ◽  
Changwu Zheng ◽  
Gang Zhao ◽  
Yongjia Shang
Keyword(s):  
Hydrogen Bond ◽  
Carboxylic Acid ◽  
Michael Addition ◽  
Acid Ester ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Carboxylic Acid Ester ◽  
Asymmetric Michael Addition ◽  
Multiple Hydrogen Bond ◽  
Hydrogen Bond Donors

Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones

2017 ◽  
Vol 15 (29) ◽  
pp. 6089-6092 ◽  
Author(s):  
Feng Yin ◽  
Ainash Garifullina ◽  
Fujie Tanaka
Keyword(s):  
Carboxylic Acid ◽  
Michael Addition ◽  
Addition Reaction ◽  
Reaction System ◽  
Addition Reactions ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition

An enantioselective Michael addition reaction system was developed. Using the reaction system, 5-methylpyrrolidine-3-carboxylic acid was synthesized in two steps.

ChemInform Abstract: Organocatalyzed Michael Addition Reaction by Novel (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid, a New Fused Proline.

ChemInform ◽  
2011 ◽  
Vol 42 (21) ◽  
pp. no-no
Author(s):  
David Roca-Lopez ◽  
Pedro Merino ◽  
Francisco J. Sayago ◽  
Carlos Cativiela ◽  
Raquel P. Herrera
Keyword(s):  
Carboxylic Acid ◽  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers

2015 ◽  
Vol 51 (49) ◽  
pp. 9979-9982 ◽  
Author(s):  
Jin-Miao Tian ◽  
Yong-Hai Yuan ◽  
Yong-Qiang Tu ◽  
Fu-Min Zhang ◽  
Xiao-Bo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Silyl Ether ◽  
Michael Addition Reaction ◽  
Quaternary Centers ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed and applied to an asymmetric Michael addition reaction.

Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

2014 ◽  
Vol 12 (40) ◽  
pp. 8008-8018 ◽  
Author(s):  
Ahmed Kamal ◽  
Manda Sathish ◽  
Vunnam Srinivasulu ◽  
Jadala Chetna ◽  
Kunta Chandra Shekar ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Mechanistic Studies ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition

New pyrrolidinyl-oxazole-carboxamides were synthesized and utilized as efficient organocatalysts for asymmetric Michael addition reaction. In addition, computational mechanistic studies were performed.

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