Drug-induced hierarchical self-assembly of poly(amino acid) for efficient intracellular drug delivery

The self-assembly of non-ionic amphiphiles with hydroxylated oxanorbornane head-group was controlled using amino acid units as spacers between hydrophilic and lipophilic domains to get spherical supramolecular aggregates suitable for drug delivery applications.

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Amino Acid Functional Polymers: Biomimetic Polymer Design Enabling Catalysis, Chiral Materials, and Drug Delivery

Australian Journal of Chemistry ◽

10.1071/ch16028 ◽

2016 ◽

Vol 69 (7) ◽

pp. 705 ◽

Cited By ~ 15

Author(s):

Emma R. L. Brisson ◽

Zeyun Xiao ◽

Luke A. Connal

Keyword(s):

Drug Delivery ◽

Amino Acids ◽

Amino Acid ◽

Self Assembly ◽

Building Blocks ◽

Functional Polymers ◽

Responsive Materials ◽

Biomimetic Polymer ◽

Tunable Optical Properties ◽

Natural Building

Amino acids are the natural building blocks for the world around us. Highly functional, these small molecules have unique catalytic properties, chirality, and biocompatibility. Imparting these properties to surfaces and other macromolecules is highly sought after and represents a fast-growing field. Polymers functionalized with amino acids in the side chains have tunable optical properties, pH responsiveness, biocompatibility, structure and self-assembly properties. Herein, we review the synthesis of amino acid functional polymers, discuss manipulation of available strategies to achieve the desired responsive materials, and summarize some exciting applications in catalysis, chiral particles, and drug delivery.

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Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Chemical Communications ◽

10.1039/b815918a ◽

2008 ◽

pp. 6570 ◽

Cited By ~ 325

Author(s):

Ahn Na Koo ◽

Hong Jae Lee ◽

Sung Eun Kim ◽

Jeong Ho Chang ◽

Chiyoung Park ◽

...

Keyword(s):

Drug Delivery ◽

Amino Acid ◽

Intracellular Drug Delivery ◽

Copolymer Micelles

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Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery

Biotechnology Letters ◽

10.1007/s10529-005-7838-4 ◽

2005 ◽

Vol 27 (14) ◽

pp. 977-982 ◽

Cited By ~ 9

Author(s):

Seung Rim Yang ◽

Seung Beom Kim ◽

Cheol O. Joe ◽

Jong-Duk Kim

Keyword(s):

Drug Delivery ◽

Amino Acid ◽

Amino Acid Derivatives ◽

Intracellular Drug Delivery

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Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery

RSC Advances ◽

10.1039/c5ra03423j ◽

2015 ◽

Vol 5 (40) ◽

pp. 31972-31983 ◽

Cited By ~ 14

Author(s):

Yanjuan Wu ◽

Dongfang Zhou ◽

Yanxin Qi ◽

Zhigang Xie ◽

Xuesi Chen ◽

...

Keyword(s):

Drug Delivery ◽

Amino Acid ◽

Triggered Release ◽

Intracellular Drug Delivery

Schematic illustration of DOX loading, endocytosis and intracellular microenvironment triggered release from PRDSP@DOX NPs.

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The construction and effect of physical properties on intracellular drug delivery of poly(amino acid) capsules

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2019.01.061 ◽

2019 ◽

Vol 177 ◽

pp. 178-187 ◽

Cited By ~ 1

Author(s):

Wenjuan Huang ◽

Tinghong Zhang ◽

Pengzhong Shi ◽

Dejun Yang ◽

Shan Luo ◽

...

Keyword(s):

Drug Delivery ◽

Amino Acid ◽

Physical Properties ◽

Intracellular Drug Delivery

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Effects of hydrophilic block of PAEEP-PLLA micelles on self-assembly behavior and intracellular drug delivery

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2017.11.080 ◽

2018 ◽

Vol 14 (5) ◽

pp. 1765

Author(s):

Xuhan Liu ◽

Xi Tan ◽

Rong Rao ◽

Yuanyuan Ren ◽

Xiangliang Yang ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Intracellular Drug Delivery ◽

Assembly Behavior

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Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel

Polymer Chemistry ◽

10.1039/c7py01162h ◽

2017 ◽

Vol 8 (40) ◽

pp. 6289-6299 ◽

Cited By ~ 7

Author(s):

Manuela Callari ◽

Sandy Wong ◽

Hongxu Lu ◽

Janice Aldrich-Wright ◽

Paul de Souza ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Cancer Therapy ◽

Self Assembly ◽

Triblock Copolymers ◽

Drug Carriers ◽

Multi Drug Resistance ◽

Platinum Drugs ◽

Drug Induced ◽

Dual Drug

Co-delivery of two drugs in one nanoparticle is increasingly used to overcome, for example, multi-drug resistance in cancer therapy and therefore suitable drug carriers need to be developed.

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