Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP

2005 ◽  
Vol 17 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Annie Bourdeau ◽  
Nadia Dubé ◽  
Michel L Tremblay
Keyword(s):  
Protein Tyrosine Phosphatases ◽  
Cytoplasmic Protein ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
And Function

scholarly journals Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Blood ◽  
2013 ◽  
Vol 121 (20) ◽  
pp. 4205-4220 ◽  
Author(s):  
Alexandra Mazharian ◽  
Jun Mori ◽  
Ying-Jie Wang ◽  
Silke Heising ◽  
Benjamin G. Neel ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatases ◽  
Tyrosine Phosphatases ◽  
Platelet Production ◽  
Protein Tyrosine ◽  
Key Points ◽  
And Function ◽  
Specific Deletion

Key Points The protein-tyrosine phosphatases Shp1 and Shp2 are critical regulators of megakaryocyte development, platelet production, and function. Shp1 and Shp2 perform mainly distinct functions in megakaryocytes and platelets, with little functional overlap.

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