scholarly journals Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition

Cell Reports ◽  
2018 ◽  
Vol 22 (10) ◽  
pp. 2615-2627 ◽  
Author(s):  
Clara Lopes Novo ◽  
Biola-Maria Javierre ◽  
Jonathan Cairns ◽  
Anne Segonds-Pichon ◽  
Steven W. Wingett ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Range ◽  
State Transition ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Pluripotent State

scholarly journals Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State

Stem Cells ◽  
2017 ◽  
Vol 36 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Mia L. Huang ◽  
Austen L. Michalak ◽  
Christopher J. Fisher ◽  
Mitchell Christy ◽  
Raymond A. A. Smith ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Surface ◽  
Small Molecule ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Pluripotent State ◽  
Small Molecule Antagonist

scholarly journals Distinct SoxB1 networks are required for naïve and primed pluripotency

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Andrea Corsinotti ◽  
Frederick CK Wong ◽  
Tülin Tatar ◽  
Iwona Szczerbinska ◽  
Florian Halbritter ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Self Renewal ◽  
Cell Fate Decisions ◽  
Pluripotent State

Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown. Here, we show that Sox2 can be deleted from EpiSCs with impunity. This is due to a shift in the balance of SoxB1 expression in EpiSCs, which have decreased Sox2 and increased Sox3 compared to ESCs. Consistent with functional redundancy, Sox3 can also be deleted from EpiSCs without eliminating self-renewal. However, deletion of both Sox2 and Sox3 prevents self-renewal. The overall SOXB1 levels in ESCs affect differentiation choices: neural differentiation of Sox2 heterozygous ESCs is compromised, while increased SOXB1 levels divert the ESC to EpiSC transition towards neural differentiation. Therefore, optimal SOXB1 levels are critical for each pluripotent state and for cell fate decisions during exit from naïve pluripotency.

scholarly journals Coactivators p300 and CBP Maintain the Identity of Mouse Embryonic Stem Cells by Mediating Long-Range Chromatin Structure

Stem Cells ◽  
2014 ◽  
Vol 32 (7) ◽  
pp. 1805-1816 ◽  
Author(s):  
Fang Fang ◽  
Yifeng Xu ◽  
Kai-Khen Chew ◽  
Xi Chen ◽  
Huck-Hui Ng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Range ◽  
Chromatin Structure ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

scholarly journals Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression

FEBS Journal ◽  
2015 ◽  
Vol 282 (4) ◽  
pp. 685-699 ◽  
Author(s):  
Yuan Gao ◽  
Zhuo Han ◽  
Qian Li ◽  
Yongyan Wu ◽  
Xiaoyan Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Vitamin C ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Microrna Expression ◽  
Pluripotent State

Melatonin affects hypoxia-stressed cardiomyocyte differentiation of mouse embryonic stem cells

2020 ◽  
Author(s):  
Eui-Bae Jeung ◽  
Jae-Hwan Lee ◽  
Park Seon Mi ◽  
Sunhwa Jeong ◽  
Yeong-Min Yoo
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Cardiomyocyte Differentiation
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