scholarly journals Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch

Cell Reports ◽  
2019 ◽  
Vol 28 (3) ◽  
pp. 625-639.e6 ◽  
Author(s):  
David Acton ◽  
Xiangyu Ren ◽  
Stefania Di Costanzo ◽  
Antoine Dalet ◽  
Steeve Bourane ◽  
...  
Keyword(s):  
Y1 Receptor ◽  
Excitatory Pathway

Neuropetide Y Y1 receptor deletion impairs matrix demineralization and resorption

2016 ◽  
Author(s):  
Daniela M Sousa ◽  
Francisco Conceicao ◽  
Luis Leitao ◽  
Estrela Neto ◽  
Cecilia J Alves ◽  
...  
Keyword(s):  
Y1 Receptor

Presence of the neuropeptide Y1 receptor in tenocytes and blood vessel walls in the human Achilles tendon

2009 ◽  
Vol 43 (14) ◽  
pp. 1136-1142 ◽  
Author(s):  
D Bjur ◽  
H Alfredson ◽  
S Forsgren
Keyword(s):  
Blood Vessel ◽  
Achilles Tendon ◽  
Y1 Receptor ◽  
Vessel Walls

NPY Y1 receptor like immunoreactivity exists in a subpopulation of β-endorphin immunoreactive nerve cells in the arcuate nucleus: a double immunolabelling analysis in the rat

1997 ◽  
Vol 225 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Kjell Fuxe ◽  
Barbro Tinner ◽  
Laura Caberlotto ◽  
Bernd Bunnemann ◽  
Luigi F Agnati
Keyword(s):  
Arcuate Nucleus ◽  
Nerve Cells ◽  
Y1 Receptor ◽  
Double Immunolabelling

Regulation of food intake by neuropeptide Y in goldfish

2000 ◽  
Vol 279 (3) ◽  
pp. R1025-R1034 ◽  
Author(s):  
Yuwaraj K. Narnaware ◽  
Pierre P. Peyon ◽  
Xinwei Lin ◽  
Richard E. Peter
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Mrna Levels ◽  
Food Ration ◽  
Y1 Receptor ◽  
Daily Food ◽  
Daily Food Ration ◽  
Brain Ventricle ◽  
Dose Dependent Increase ◽  
Dose Dependent

In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.

Two different signal transductions of neuropeptide Y1 receptor in SK-N-MC cells

1992 ◽  
Vol 187 (3) ◽  
pp. 1565-1571 ◽  
Author(s):  
Yasushi Shigeri ◽  
Masafumi Fujimoto
Keyword(s):  
Y1 Receptor ◽  
Signal Transductions

Synthesis and Binding Affinity of Fluorine Containing NG-acyl and -sulfonyl BIBP3226 Derivatives: Ligands for the NPY Y1 Receptor

2016 ◽  
Vol 69 (7) ◽  
pp. 746
Author(s):  
Nigel A. Lengkeek ◽  
Maxine P. Roberts ◽  
Lei Zhang ◽  
I-Chieh J. Lee ◽  
Christopher J. R. Fookes ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Emission Tomography ◽  
Tumour Imaging ◽  
Y1 Receptor ◽  
Important Amino Acid ◽  
Positron Emission ◽  
Npy Receptor ◽  
Almost All ◽  
Derivatives Of ◽  
Pet Radiopharmaceuticals

The neuropeptide Y (NPY) receptors are abundant in a range of tumours hence are a molecular target for tumour imaging and therapy, particularly by the use of radiolabelled molecules. NG-Substituted derivatives of the NPY receptor antagonist, BIBP3226, were prepared aiming to improve its current usability and to incorporate a positron-emitting radioisotope for development in positron emission tomography (PET) radiopharmaceuticals. The BIBP3226 derivatives were prepared in seven steps while retaining the critically important amino acid chirality. The acyl derivative retained acceptable ligand binding, however the sulfonyl derivatives lost almost all binding affinity.

scholarly journals Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents

1998 ◽  
Vol 125 (3) ◽  
pp. 549-555 ◽  
Author(s):  
H A Wieland ◽  
W Engel ◽  
W Eberlein ◽  
K Rudolf ◽  
H N Doods
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
The Novel ◽  
Y1 Receptor ◽  
Subtype Selectivity

scholarly journals The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat

Endocrinology ◽  
2002 ◽  
Vol 143 (1) ◽  
pp. 191-197 ◽  
Author(s):  
Christine L. Chaffer ◽  
Margaret J. Morris
Keyword(s):  
Feeding Response ◽  
Y1 Receptor ◽  
Melanin Concentrating Hormone

Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi α subunit function in CHO cells

2008 ◽  
Vol 579 (1-3) ◽  
pp. 13-25 ◽  
Author(s):  
Steven L. Parker ◽  
Michael S. Parker ◽  
Renu Sah ◽  
Ambikaipakan Balasubramaniam ◽  
Floyd R. Sallee
Keyword(s):  
Neuropeptide Y ◽  
Pertussis Toxin ◽  
Cho Cells ◽  
Α Subunit ◽  
Y1 Receptor ◽  
Subunit Function ◽  
Receptor Dimers

Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

2009 ◽  
Vol 19 (16) ◽  
pp. 4781-4785 ◽  
Author(s):  
Kaimei Cho ◽  
Makoto Ando ◽  
Kensuke Kobayashi ◽  
Hiroshi Miyazoe ◽  
Toshiaki Tsujino ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Y1 Receptor
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