scholarly journals Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways

Cell Reports ◽  
2020 ◽  
Vol 31 (10) ◽  
pp. 107732 ◽  
Author(s):  
Alessio Strano ◽  
Eleanor Tuck ◽  
Victoria E. Stubbs ◽  
Frederick J. Livesey
Keyword(s):  
Signaling Pathways ◽  
Neural Differentiation ◽  
Developmental Signaling

scholarly journals Comparative approaches to the study of physiology: Drosophila as a physiological tool

2013 ◽  
Vol 304 (3) ◽  
pp. R177-R188 ◽  
Author(s):  
Wendi S. Neckameyer ◽  
Kathryn J. Argue
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Pattern Formation ◽  
Signaling Pathways ◽  
Human Disease ◽  
Cognitive Disorders ◽  
Model System ◽  
Critical Questions ◽  
Developmental Signaling ◽  
Shed Light

Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, the way in which pain circuits are integrated to elicit responses from sensation, as well as the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.

scholarly journals Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways

2018 ◽  
Vol 25 (9) ◽  
pp. 1095-1106.e23 ◽  
Author(s):  
Silke Brand ◽  
Sayantani Roy ◽  
Peter Schröder ◽  
Bernd Rathmer ◽  
Jessica Roos ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
In Silico ◽  
Target Identification ◽  
Developmental Signaling

scholarly journals Communication codes in developmental signaling pathways

Development ◽  
2019 ◽  
Vol 146 (12) ◽  
pp. dev170977 ◽  
Author(s):  
Pulin Li ◽  
Michael B. Elowitz
Keyword(s):  
Signaling Pathways ◽  
Developmental Signaling
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