Continuous countercurrent deterpenation of lemon essential oil by means of supercritical carbon dioxide: Experimental data and process modelling

2008 ◽  
Vol 63 (3) ◽  
pp. 651-661 ◽  
Author(s):  
Fausto Gironi ◽  
Marco Maschietti
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Essential Oil ◽  
Process Modelling ◽  
Continuous Countercurrent ◽  
Supercritical Carbon

Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations

2021 ◽  
Author(s):  
Gholamhossein Sodeifian ◽  
Seyed Ali Sajadian ◽  
Fariba Razmimanesh ◽  
Seyed Mojtaba Hazaveie
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Binary System ◽  
Supercritical Carbon Dioxide ◽  
Ternary System ◽  
Drug Solubility ◽  
Analysis Method ◽  
Empirical Correlations ◽  
Semiempirical Models ◽  
Supercritical Carbon

Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 1.70×10− 6 and 8.02×10− 4, while drug solubility in the SC-CO2 with cosolvent varied from 2.7×10− 5 to 1.96×10− 4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD,%= 6.45, Radj= 0.995.

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