Obese Humans With Nonalcoholic Fatty Liver Disease Display Alterations in Fecal Microbiota and Volatile Organic Compounds

2013 ◽  
Vol 11 (7) ◽  
pp. 876-878 ◽  
Author(s):  
Jerome Boursier ◽  
John F. Rawls ◽  
Anna Mae Diehl
Author(s):  
Phillipp Hartmann ◽  
Bernd Schnabl

AbstractAlcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are important causes of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of both ALD and NAFLD. Here we describe associated changes in the intestinal microbiota, and we detail randomized clinical trials in ALD and NAFLD which evaluate treatments modulating the intestinal microbiome including fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and antibiotics. Finally, we discuss precision medicine approaches targeting the intestinal microbiome to ameliorate ALD and NAFLD.


2013 ◽  
Vol 11 (7) ◽  
pp. 868-875.e3 ◽  
Author(s):  
Maitreyi Raman ◽  
Iftikhar Ahmed ◽  
Patrick M. Gillevet ◽  
Chris S. Probert ◽  
Norman M. Ratcliffe ◽  
...  

2017 ◽  
Vol 112 ◽  
pp. S499
Author(s):  
Mohammad Nasser Kabbany ◽  
Zade Akras ◽  
Praveen Kumar Conjeevaram Selvakumar ◽  
Ghassoub Rifai ◽  
David Grove ◽  
...  

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