scholarly journals Long-term Efficacy of Tenofovir Disoproxil Fumarate Monotherapy for Multidrug-Resistant Chronic HBV infection

2019 ◽  
Vol 17 (7) ◽  
pp. 1348-1355.e2 ◽  
Author(s):  
Hye Won Lee ◽  
Jun Yong Park ◽  
Jin Woo Lee ◽  
Ki Tae Yoon ◽  
Chang Wook Kim ◽  
...  
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Multidrug Resistant ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Term Efficacy ◽  
Chronic Hbv

Long-term Effects of Treatment for Chronic HBV Infection on Patient-Reported Outcomes

2019 ◽  
Vol 17 (8) ◽  
pp. 1641-1642.e1 ◽  
Author(s):  
Zobair M. Younossi ◽  
Maria Stepanova ◽  
Issah Younossi ◽  
Calvin Q. Pan ◽  
Harry L.A. Janssen ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Hbv Infection ◽  
Long Term Effects ◽  
Chronic Hbv Infection ◽  
Patient Reported ◽  
Chronic Hbv

scholarly journals Serum HBV RNA Dynamic and Drug Withdrawal Predictor Value in Patients With Chronic HBV Infection on Long-term Nucleos(t)ide Analogue (NA) Therapy

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yayun Liu ◽  
Jianya Xue ◽  
Wei Liao ◽  
Hongli Yan ◽  
Xuesong Liang
Keyword(s):  
Drug Withdrawal ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Chronic Hbv

LONG TERM FOLLOW-UP OF CHRONIC HBV INFECTION: ANY TREATMENT IS BETTER THAN NO TREATMENT?

2005 ◽  
Vol 40 (5) ◽  
pp. 685
Author(s):  
A Figueiredo ◽  
S Jacinto ◽  
F Santos ◽  
I Afonso ◽  
J Cabral ◽  
...  
Keyword(s):  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Long Term Follow Up ◽  
Chronic Hbv ◽  
Better Than

scholarly journals Distribution Evaluation of Tenofovir in the Breast Milk of Mothers With HBeAg-Positive Chronic HBV Infection After Treatment With Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate by a Sensitive UPLC-MS/MS Method

2021 ◽  
Vol 12 ◽  
Author(s):  
Na Yang ◽  
Guanlun Zhou ◽  
Xiaoliang Cheng ◽  
Jun He ◽  
Yan Chen ◽  
...  
Keyword(s):  
Breast Milk ◽  
Tenofovir Disoproxil Fumarate ◽  
Multiple Reaction Monitoring ◽  
Hbv Infection ◽  
Mass Spectrometry Analysis ◽  
Chronic Hbv Infection ◽  
Spectrometry Analysis ◽  
Chronic Hepatitis B Virus ◽  
Chronic Hbv ◽  
Tenofovir Alafenamide

Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir (TFV) that has been approved for the treatment of chronic hepatitis B virus (HBV) infection. It has greater plasma stability and more favorable renal safety than tenofovir disoproxil fumarate (TDF), the first approved oral prodrug of TFV. However, the distribution of TFV in the breast milk of mothers treated with TAF is still unclear. In this study, sixteen participants with chronic HBV infection were enrolled and received antiretroviral therapy with 25 mg of TAF or 300 mg of TDF daily from 24 to 28 weeks of gestation until the 4th week postpartum. For the first time, the distribution of TFV in the breast milk of mothers with chronic HBV infection treated with TAF and its difference from TDF were evaluated by using a sensitive UPLC–MS/MS method. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C18 column (1.7 µm 2.1 × 100 mm). Mass spectrometry analysis was performed in positive electrospray ionization mode and multiple reaction monitoring (MRM) conditions of transitions m/z 288.1→176.2 for TFV. This method was linear from 0.5 to 500 ng/ml. Surprisingly, on the third postpartum day, the median Cmax of TFV in the breast milk was much higher in the mothers treated with TAF (101.2 ng/ml) than TDF (21.6 ng/ml) at a similar Tmax of 4 h. Accordingly, the median AUC0-8 value was 755.6 ng h/mL in the mothers taking TAF, which was at a 5-fold higher level than TDF. The concentration of TFV in the breast milk of mothers in both groups decreased with increasing lactation time. These data indicated that there was a relatively higher exposure of TFV in the breast milk of mothers taking TAF, despite the lower dosage compared to TDF. This study provides support for further evaluating the safety of breastfeeding after the administration of TAF and TDF.

Changes in Renal Function in Patients With Chronic HBV Infection Treated With Tenofovir Disoproxil Fumarate vs Entecavir

2019 ◽  
Vol 17 (5) ◽  
pp. 948-956.e1 ◽  
Author(s):  
Sam Trinh ◽  
An K. Le ◽  
Ellen T. Chang ◽  
Joseph Hoang ◽  
Donghak Jeong ◽  
...  
Keyword(s):  
Renal Function ◽  
Tenofovir Disoproxil Fumarate ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Chronic Hbv

scholarly journals Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries

2020 ◽  
Vol 18 (2) ◽  
pp. 457-467.e21 ◽  
Author(s):  
Jin-Lin Hou ◽  
Wei Zhao ◽  
Changhyeong Lee ◽  
Hie-Won Hann ◽  
Cheng-Yuan Peng ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Term Treatment ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Long Term Treatment ◽  
Chronic Hbv
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