scholarly journals Diagnostic Performance of Vibration-Controlled Transient Elastography in Liver Transplant Recipients

2020 ◽  
Author(s):  
Mohammad Shadab Siddiqui ◽  
Michael O. Idowu ◽  
Katharine Stromberg ◽  
Adam Sima ◽  
Emily Lee ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Diagnostic Performance ◽  
Transient Elastography ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

T1944 TRANSIENT ELASTOGRAPHY (Fibroscan) in Hepatitis C Native Liver vs. Liver Transplant Recipients with Recurrence: Diagnostic Performance and Predictors of Advanced Fibrosis

2008 ◽  
Vol 134 (4) ◽  
pp. A-827
Author(s):  
José C. Marin-Gabriel ◽  
J.B. De-la-Cruz ◽  
María Tocado ◽  
Yolanda Rodriguez-Gil ◽  
Ana M. Martin-Algibez ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Liver Transplant ◽  
Diagnostic Performance ◽  
Transient Elastography ◽  
Advanced Fibrosis ◽  
Transplant Recipients ◽  
Native Liver ◽  
Liver Transplant Recipients

Late allograft fibrosis in pediatric liver transplant recipients: Assessed by histology and transient elastography

2019 ◽  
Vol 23 (7) ◽  
Author(s):  
Atchariya Chanpong ◽  
Napat Angkathunyakul ◽  
Pattana Sornmayura ◽  
Pornthep Tanpowpong ◽  
Chatmanee Lertudomphonwanit ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Transient Elastography ◽  
Transplant Recipients ◽  
Pediatric Liver ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant

scholarly journals Transient Hepatic Elastography in the Assessment of Liver Fibrosis in Patients After Liver Transplantation

2021 ◽  
Vol 51 (3) ◽  
Author(s):  
Larisse Longo ◽  
Henrique Mariano Pereira Matheus ◽  
Deivid Cruz dos Santos ◽  
Matheus Trucollo Michalczuk ◽  
Carlos Thadeu Schmidt Cersk ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Biopsy ◽  
Liver Transplant ◽  
Transient Elastography ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Glutamyl Transferase ◽  
Liver Transplant Recipients

Introduction and Objectives. Liver biopsy is the gold standard for assessing fibrosis and inflammation in liver transplant recipients. As this study has risks, the use of noninvasive tools has been proposed, including transient elastography, a method that needs further study in this population, which is the purpose of this research. Material and methods. Demographic and clinical data were collected retrospectively in patients who received a liver transplant, underwent liver biopsy and transient elastography less than 1 year apart. Sensitivity, specificity, diagnostic accuracy and Kappa concordance test between the two methods were determined. Results. Of 356 patients evaluated after transplantation, 45 underwent liver biopsy and transient elastography within 1 year; 60.0% were male and 75.6% had hepatitis C virus infection. At the time of transient elastography, laboratory values were: mean total bilirubin 1.5 mg/dL, alanine aminotransferase 108.1 U/L, aspartate aminotransferase, 101.6 U/L, alkaline phosphatase, 96.0 U/L and gamma-glutamyl transferase 9.0 U/L. The main indications for liver biopsy were assessment for rejection, hepatitis C virus infection or both. According to liver biopsy, 82.2% presented absent or minimal fibrosis and 75.6% had no inflammation. Acute cellular rejection was present in 20.0% of cases. A cut-off point of > 9.5 kPa was used to define advanced fibrosis, while a value < 7.5 kPa was set to indicate absent or mild fibrosis. Poor agreement was found between transient elastography and liver biopsy for these categories (Kappa 0.125, sensitivity 69.5%, specificity 66.7%) and for specific stages of fibrosis (Kappa 0.095). Conclusions. Accuracy, sensitivity and specificity were low for fibrosis staging when comparing transient elastography with liver biopsy. In liver transplant recipients, transient elastography would overestimate fibrosis, probably due to inflammation secondary to other causes.

Routine Liver Elastography Could Predict Actuarial Survival after Liver Transplantation

2019 ◽  
Vol 28 (3) ◽  
pp. 271-277 ◽  
Author(s):  
Jan Pfeiffenberger ◽  
Daniel Hornuss ◽  
Philip Houben ◽  
Cyrill Wehling ◽  
Rebecca Von Haken ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Clinical Outcome ◽  
Liver Transplant ◽  
Transient Elastography ◽  
Univariate Analysis ◽  
Gamma Glutamyl Transferase ◽  
Transplant Recipients ◽  
Actuarial Survival ◽  
Glutamyl Transferase ◽  
Liver Transplant Recipients

Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. Results: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 – 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051–1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001–1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986–0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070–0.895; p=0.033). Conclusion: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients.

Assessment of Fibrosis in Liver Transplant Recipients: Diagnostic Performance of Shear Wave Elastography (SWE) and Correlation of SWE Findings With Biopsy Results

2019 ◽  
Vol 213 (6) ◽  
pp. W264-W271 ◽  
Author(s):  
Corinne Deurdulian ◽  
Edward G. Grant ◽  
Hisham Tchelepi ◽  
Paul T. Latterman ◽  
Jeremy T. Paluch ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Shear Wave ◽  
Diagnostic Performance ◽  
Shear Wave Elastography ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

The use of transient elastography and non-invasive serum markers of fibrosis in pediatric liver transplant recipients

2013 ◽  
Vol 17 (6) ◽  
pp. 525-534 ◽  
Author(s):  
Imeke Goldschmidt ◽  
Henrik Stieghorst ◽  
Mona Munteanu ◽  
Thierry Poynard ◽  
Jerome Schlue ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Transient Elastography ◽  
Serum Markers ◽  
Transplant Recipients ◽  
Non Invasive ◽  
Pediatric Liver ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant

Detection of graft fibrosis by vibration‐controlled transient elastography in pediatric liver transplant recipients

2020 ◽  
Vol 24 (6) ◽  
Author(s):  
Peter Costa ◽  
Debora Kogan‐Liberman ◽  
Bryan Rudolph ◽  
Ellen Silver ◽  
Michelle Ewart ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Transient Elastography ◽  
Transplant Recipients ◽  
Pediatric Liver ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant
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