Membrane composition modulates the interaction between a new class of antineoplastic agents deriving from aromatic 2-chloroethylureas and lipid bilayers: a solid-state NMR study

2007 ◽  
Vol 146 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Francis Cronier ◽  
Alexandre Patenaude ◽  
René C.-Gaudreault ◽  
Michèle Auger
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
Antineoplastic Agents ◽  
Membrane Composition ◽  
New Class ◽  
Nmr Study

Interaction between lipid bilayers and a new class of antineoplastic agents derived from arylchloroethylurea: a 2H solid-state NMR study

1998 ◽  
Vol 76 (2-3) ◽  
pp. 465-471
Author(s):  
Audrey Saint-Laurent ◽  
Nadine Boudreau ◽  
René C.-Gaudreault ◽  
Patrick Poyet ◽  
Michèle Auger
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
Antineoplastic Agents ◽  
New Class ◽  
Nmr Study

Interaction between lipid bilayers and a new class of antineoplastic agents derived from arylchloroethylurea: a 2H solid-state NMR study

1998 ◽  
Vol 76 (2-3) ◽  
pp. 465-471 ◽  
Author(s):  
Audrey Saint-Laurent ◽  
Nadine Boudreau ◽  
René C.-Gaudreault ◽  
Patrick Poyet ◽  
Michèle Auger
Keyword(s):  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Antineoplastic Agents ◽  
Acyl Chain ◽  
Resonance Spectroscopy ◽  
Interfacial Region ◽  
Molar Ratios ◽  
New Class ◽  
Nmr Study ◽  
Acyl Chains

We have investigated the interaction between a new class of antineoplastic agents derived from arylchloroethylurea (CEU) and model membrane of dimyristoylphosphatidylcholine by deuterium nuclear magnetic resonance spectroscopy. The results indicate that the drug incorporates in the bilayer and causes an increase of the lipid acyl chain order, this effect being greater close to the interfacial region of the lipid bilayer. The increase in ordering is dependent on the nature (degree of ramification, length of the alkyl chain, and presence of a sulfur atom) as well as on the position of the R substituent and is correlated with the cytotoxicity of the drugs. More specifically, the more cytotoxic drugs, such as 4-sec-butyl CEU, are those having a bulky ramified substituent and those for which the ordering effect on the lipid bilayer is the smallest. On the other hand, the ordering effect is greater and seen all along the lipid acyl chains for the long-chain CEUs, such as n-hexadecyl CEU, which have been shown to have very weak cytotoxic activity. Finally, the results obtained as a function of the drug concentration indicate that the ordering effect is seen for lipid to drug molar ratios as low as 20:1.Key words: deuterium, NMR, membrane, arylchloroethylurea, liposome.

scholarly journals Solid-State NMR Study of the Human Peripheral Cannabinoid Receptor CB2 in Lipid Bilayers

2009 ◽  
Vol 96 (3) ◽  
pp. 677a
Author(s):  
Tomohiro Kimura ◽  
Alexei A. Yeliseev ◽  
Krishna Vukoti ◽  
Klaus Gawrisch
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
Cannabinoid Receptor ◽  
Nmr Study

The adsorption of chromocene and ferrocene on silica: A solid-state NMR study

2013 ◽  
Vol 744 ◽  
pp. 119-124 ◽  
Author(s):  
Kyle J. Cluff ◽  
Michael Schnellbach ◽  
Casie R. Hilliard ◽  
Janet Blümel
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Nmr Study

Investigating Sorption on Iron−Oxyhydroxide Soil Minerals by Solid-State NMR Spectroscopy:  A6Li MAS NMR Study of Adsorption and Absorption on Goethite

2005 ◽  
Vol 109 (39) ◽  
pp. 18310-18315 ◽  
Author(s):  
Ulla Gro Nielsen ◽  
Younkee Paik ◽  
Keinia Julmis ◽  
Martin A. A. Schoonen ◽  
Richard J. Reeder ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Mas Nmr ◽  
Iron Oxyhydroxide ◽  
Soil Minerals ◽  
Solid State Nmr Spectroscopy ◽  
Nmr Study
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