INHALATION DEVICE TECHNIQUE ERRORS AMONG PATIENTS WITH OBSTRUCTIVE LUNG DISEASES USING METERED-DOSE INHALERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF US STUDIES

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 784A-785A
Author(s):  
MARYAM NAVAIE ◽  
VAIDYANATHAN GANAPATHY ◽  
SOOJIN CHO-REYES ◽  
BARTOLOME CELLI ◽  
CAROLE DEMBEK ◽  
...  
2020 ◽  
Vol 55 (12) ◽  
pp. 3268-3278
Author(s):  
Laura Payares‐Salamanca ◽  
Sandra Contreras‐Arrieta ◽  
Victor Florez‐García ◽  
Alexander Barrios‐Sanjuanelo ◽  
Ivan Stand‐Niño ◽  
...  

2020 ◽  
Author(s):  
Laura Payares Salamanca ◽  
Sandra Contreras Arrieta ◽  
Victor Florez Garcia ◽  
Alexander Barrios Sanjuanelo ◽  
Ivan Stand Ni o ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
pp. 1720336 ◽  
Author(s):  
Samuel Lopes ◽  
Jaime Eduardo Cecilio Hallak ◽  
João Paulo Machado de Sousa ◽  
Flávia de Lima Osório

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Henk Versteeg ◽  
Abdul Qaiyum Shaik

Pressurized metered-dose inhalers (pMDIs) have been the most effective therapeutic treatment for controlling lung diseases such as asthma and COPD. The flow through a two-orifice system of pMDI is very complex and poorly understood. Previous experimental work has shown that metastability may play a significant role in determining the flow conditions inside pMDIs. In this paper, we present the findings of a homogeneous equilibrium model with those of a delayed equilibrium model (DEM) accounting for propellant metastability. These results are compared with the available experimental and numerical predictions Further, the DEM was applied with HFA propellants R134A and R227, and the results were compared with traditional propellant R12.


PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17479 ◽  
Author(s):  
Darren R. Brenner ◽  
John R. McLaughlin ◽  
Rayjean J. Hung

2021 ◽  
Vol 11 (31) ◽  
Author(s):  
Chinemerem C. Nwaozuzu ◽  
Kingsley C. Partick-Iwuanyanwu ◽  
Stephen O. Abah

Background. There is fast-growing epidemiologic evidence of the effects of environmental chemicals on respiratory health. Polycyclic aromatic hydrocarbons (PAHs) have been linked with airway obstruction common in asthma and/or asthma exacerbation, and chronic bronchitis and emphysema. Objectives. A systematic review of the association between exposure to PAHs and obstructive lung diseases is not yet available. The present systematic review aims to evaluate the evidence available in epidemiological studies that have associated PAHs with obstructive lung diseases such as asthma, chronic bronchitis, emphysema. Methods. We performed a systematic literature search on PubMed, Google Scholar, and Scopus databases using relevant keywords and guided by predesigned eligibility criteria. Results. From the total of 30 articles reviewed, 16 articles examined the link between PAHs and lung function in both adults and children. Twelve articles investigated the association between PAHs and asthma, asthma biomarkers, and/or asthma symptoms in children. Two articles studied the relationship between PAHs and fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation and the relationship between PAHs and obstructive lung diseases and infections, respectively. One study assessed exposure to daily ambient PAHs and cough occurrence. Discussion. Twenty-seven studies found an association between PAHs and asthma and reduced lung function. In children it is reinforced by studies on prenatal and postnatal exposure, whereas in adults, reductions in lung function tests marked by low forced expiratory volume in 1 second, (FEV1), forced vital capacity (FVC), and forced expiratory flow (FEF25–75%) were the major health outcomes. Some studies recorded contrasting results: insignificant and/or no association between the two variables of interest. The studies reviewed had limitations ranging from small sample size, to the use of cross-sectional rather than longitudinal study design. Conclusions. The literature reviewed in the present study largely suggest positive correlations between PAHs and obstructive lung diseases marked mainly by asthma and reduced respiratory function. This review was registered with PROSPERO (Registration no: CRD42020212894) Competing Interests. The authors declare no competing financial interests.


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