Design space and robustness analysis of batch and counter-current frontal chromatography processes for the removal of antibody aggregates

2020 ◽  
Vol 1619 ◽  
pp. 460943 ◽  
Author(s):  
Sebastian Vogg ◽  
Thomas Müller-Späth ◽  
Massimo Morbidelli
Author(s):  
Donald R. Houser ◽  
Anthony F. Luscher ◽  
Isaias Regalado

Abstract The optimum solution for a gear design depends upon the optimization criteria used; also, the performance of the optimum may be affected due to variations in the operating conditions or the existence of manufacturing errors. In order to minimize the effects of these variations, it is necessary to perform a robustness analysis during the design process. This paper discuss the development of a procedure for the robust optimization of gears considering multiple objectives, as well as a preliminary exploration of the design space and a sensitivity analysis to manufacturing errors for a particular example of spur and helical gears.


1962 ◽  
Vol 40 (2) ◽  
pp. 283-289 ◽  
Author(s):  
Darrell N. Ward ◽  
Earl F. Walborg ◽  
Harry S. Lipscomb ◽  
Roger Guillemin

ABSTRACT Fractionation of monkey pituitary glands gave an oxytocin fraction in low yield which showed a counter-current distribution coefficient equivalent to that obtained with oxytocin from other species. Fractionation and chromatography of monkey vasopressin on carboxymethyl cellulose gave arginine-vasopressin of 60% purity, based on amino acid analysis and specific activity. Counter-current distribution on a small scale gave arginine-vasopressin of 89% purity. Reports by others that monkey pituitary glands contain arginine-vasopressin, based on pharmacological activities, are substantiated by the chemical data presented here.


2018 ◽  
Author(s):  
Bassem Hallak ◽  
N. Linn ◽  
Eckehard Specht ◽  
Fabian Herz

2021 ◽  
Author(s):  
Luis Salas Nunez ◽  
Jimmy C. Tai ◽  
Dimitri N. Mavris

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