Zn/Al Layered double hydroxides nanostructure as effective controlled release vehicle of nicotinic acid for topical applications

2021 ◽  
Vol 215 ◽  
pp. 106304
Author(s):  
Phumelele E. Kleyi ◽  
Prenesha Mudaly ◽  
Sreejarani Kesavan Pillai ◽  
Marinda de Beer
Keyword(s):  
Controlled Release ◽  
Nicotinic Acid ◽  
Layered Double Hydroxides ◽  
Double Hydroxides ◽  
Topical Applications

Inorganic layered double hydroxides as a 4-hexyl resorcinol delivery system for topical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77709-77716 ◽  
Author(s):  
Damodar Mosangi ◽  
Sreejarani Kesavan Pillai ◽  
Lumbidzani Moyo ◽  
Suprakas Sinha Ray
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Layered Double Hydroxides ◽  
Skin Tone ◽  
Precipitation Method ◽  
Co Precipitation ◽  
Double Hydroxide ◽  
Double Hydroxides ◽  
Topical Applications

In this study, the hydrophobic even skin tone active, 4-hexylresorcinol is intercalated into a Zn–Al layered double hydroxide by co-precipitation method and used as controlled release ingredient in a skin care formulation.

Antibiotic-anionic Clay Matrix Used for Drug Controlled Release

2018 ◽  
Vol 69 (2) ◽  
pp. 321-323
Author(s):  
Georgeta Zegan ◽  
Elena Mihaela Carausu ◽  
Loredana Golovcencu ◽  
Alina Sodor Botezatu ◽  
Eduard Radu Cernei ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Bioactive Molecules ◽  
Drug Controlled Release ◽  
Anionic Clays ◽  
Anionic Clay ◽  
Toxicological Studies ◽  
High Efficient ◽  
Clay Matrix ◽  
Double Hydroxides

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

A controlled release strategy of antifouling agent in coating based on intercalated layered double hydroxides

2016 ◽  
Vol 172 ◽  
pp. 105-108 ◽  
Author(s):  
Zhiyong Sun ◽  
Lianghua Gu ◽  
Jiyong Zheng ◽  
Jinwei Zhang ◽  
Li Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Antifouling Agent ◽  
Double Hydroxides ◽  
Release Strategy

Bio-Resorbable Nanoceramics for Gene and Drug Delivery

MRS Bulletin ◽  
2004 ◽  
Vol 29 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Waltraud M. Kriven ◽  
Seo-Young Kwak ◽  
Matthew A. Wallig ◽  
Jin-Ho Choy
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Negative Charge ◽  
Acidic Environment ◽  
Biological Cells ◽  
Double Hydroxides ◽  
Or Genes

AbstractNanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, theirin vivoandin vitrocytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

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