Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children

2020 ◽  
Vol 211 ◽  
pp. 108319 ◽  
Author(s):  
Andrea Vecchione ◽  
Roberta Di Fonte ◽  
Jolanda Gerosa ◽  
Tatiana Jofra ◽  
Maria Pia Cicalese ◽  
...  
Author(s):  
Devi Dayal ◽  
Saniya Gupta ◽  
Dhvani Raithatha ◽  
Muralidharan Jayashree

Abstract The redistribution of healthcare resources for coronavirus 2019 (COVID-19) pandemic has resulted in unintentional neglect of essential non-COVID-19 care (1). In low- and lower-middle income countries (LMIC), the already overstretched healthcare systems have crumbled under the COVID-19 pressure (2). Additionally, hardline lockdown restrictions, and fear of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in healthcare settings have forced patients with non-COVID-19 illnesses to stay home and suffer until their illness deteriorates substantially, and sometimes irreversibly. The impact of COVID-19 on the pediatric population has so far been mild, except in children with comorbidities (3). However, children who develop new time-sensitive non-COVID-19 illnesses during the pandemic are at risk of worsening or death due to compromised access to hospital care. In particular, children with new-onset type 1 diabetes (T1D) may progress rapidly to diabetic ketoacidosis (DKA) if treatment with insulin is delayed, and are therefore at risk of increased morbidity and mortality.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 16-OR
Author(s):  
METTE DUE-CHRISTENSEN ◽  
LENE E. JOENSEN ◽  
SOPHIE SARRE ◽  
JULIE L. WAD ◽  
EWA ROMANCZUK ◽  
...  

Author(s):  
Yuichi Nishioka ◽  
Tatsuya Noda ◽  
Sadanori Okada ◽  
Tomoya Myojin ◽  
Shinichiro Kubo ◽  
...  

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
William E. Novotny ◽  
Irma Fiordalisi ◽  
Cynthia P. Keel ◽  
Glenn D. Harris

Diabetes Care ◽  
2009 ◽  
Vol 32 (12) ◽  
pp. e154-e154 ◽  
Author(s):  
L. Mastrandrea ◽  
J. Yu ◽  
T. Behrens ◽  
J. Buchlis ◽  
C. Albini ◽  
...  

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