Relationship between individual forces of each quadriceps head during low-load knee extension and cartilage thickness and knee pain in women with knee osteoarthritis

Abstract Background: Blood flow restricted low-load exercise (LL-BFR) has been shown to elicit beneficial adaptations in muscle size and strength. The aim was to investigate if LL-BRF was feasible in patients with knee pain in a rehabilitation setting. A secondary objective was to investigate functional performance, knee muscle strength and patient-reported outcomes.Methods: Data were collected from April-June 2018. Patients with knee Osteoarthritis or knee pain/functional loss after previous knee surgery were included. LL-BRF was performed twice weekly for 4-8 weeks as unilateral leg press with an individualized pressure (40% LOP) at 30% of one repetition maximum. Two protocols were tested (3-4 rounds, 30 second pauses). Patients were assessed by a 30-second chair-stand-test, Timed Up & Go, thigh circumference (TC), knee extensor strength (MVC) by handheld dynamometer, and completed the Knee Osteoarthritis Outcome Score (KOOS) score at baseline and follow-up.Results: Adherence to training was 95.6%. Few and minor adverse events were observed. One opatient dropped out due to pain aggravation in relation to baseline testing. Scores on three out of five KOOS subscales improved more than 10 points. Also, functional tests and MVC of the affected limb improved (p ≤ 0.05). Conclusion: The study indicates that supervised LL-BFR is feasible in patients with knee pain. At follow-up, the patients experienced subjective and functional gains.Trial registration: Danish Data Protection Agency (Journal No 1-16-02-90-18).

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Relationship between alignment and cartilage thickness in patients with non-traumatic and post-traumatic knee osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2019.01.002 ◽

2019 ◽

Vol 27 (4) ◽

pp. 630-637

Author(s):

S.M. Robbins ◽

F. Abram ◽

M. Boily ◽

J.-P. Pelletier ◽

J. Martel-Pelletier

Keyword(s):

Knee Osteoarthritis ◽

Cartilage Thickness ◽

Post Traumatic ◽

And Cartilage

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THU0435 ASSESING THE EFFECTS OF PULSED ULTRASOUND TREATMENT ON PAIN, FUNCTIONALITY, SYNOVIAL FLUID AND CARTILAGE THICKNESS, IN KNEE OSTEOARTHRITIS

10.1136/annrheumdis-2019-eular.6322 ◽

2019 ◽

Author(s):

Ali Karakas ◽

Muhammed Abdulkerim Şahin ◽

Hülya Ellidokuz ◽

Banu Dilek ◽

Özlem Şenocak

Keyword(s):

Synovial Fluid ◽

Knee Osteoarthritis ◽

Cartilage Thickness ◽

Ultrasound Treatment ◽

Pulsed Ultrasound ◽

And Cartilage

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Faculty Opinions recommendation of Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717954617.793462828 ◽

2012 ◽

Author(s):

Joanne Jordan ◽

Amanda Nelson

Keyword(s):

Randomised Controlled Trial ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Controlled Trial ◽

Randomised Controlled

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Efficacy and safety of sprifermin injection for knee osteoarthritis treatment: a meta-analysis

Arthritis Research & Therapy ◽

10.1186/s13075-021-02488-w ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Ni Zeng ◽

Xin-Yuan Chen ◽

Zhi-Peng Yan ◽

Jie-Ting Li ◽

Tao Liao ◽

...

Keyword(s):

Adverse Events ◽

Knee Osteoarthritis ◽

Meta Analysis ◽

Placebo Treatment ◽

Cartilage Volume ◽

Cartilage Thickness ◽

Random Effects Models ◽

Structural Progression ◽

Significant Difference ◽

Mean Differences

Abstract Objective To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment for patients with knee osteoarthritis (KOA). Method We systematically searched the literature for studies that compared long-term outcomes between sprifermin and placebo injections for KOA treatment. Meta-analysis was performed with RevMan5.3 using an inverse variance approach with fixed or random effects models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Results Eight studies were included. Overall, there was significantly less improvement of WOMAC total scores in patients receiving sprifermin, compared with the placebo (mean difference (MD) = 3.23, 95% CI 0.76–5.69; I2 = 0%; P = 0.01). Further, sprifermin injection patients gained more, and lost less, cartilage thickness and volume in total femorotibial joint (cartilage thickness: standardized mean differences (SMD) = 0.55, 95% CI 0.26–0.84; I2 = 78%; P = 0.0002; cartilage volume: SMD = 0.39, 95% CI 0.20–0.58; I2 = 49%; P < 0.0001). Changes in the cartilage surface morphology of the medial tibio-femoral joint (MD = −0.30, 95% CI −0.44 to −0.16; I2 = 0%; P < 0.0001) and patello-femoral joint (MD = −0.22; 95% CI −0.37 to −0.07; I2 = 0%; P = 0.004) showed a significant difference between the sprifermin and placebo injections. Moreover, there were no significant differences between sprifermin and the placebo in the risk of treatment-emergent adverse events (OR = 1.05; 95% CI 0.52–2.14; I2 = 48%; P = 0.89). Conclusion The data from the included studies provide strong evidence to determine the effect of intra-articular sprifermin on joint structure in individuals with KOA and show no specific adverse effects. Nevertheless, intra-articular sprifermin did not likely have any positive effect on symptom alleviation.

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