Tuberculous spondylitis following intravesical bcg-instillation in the treatment of transitional cell carcinoma: Case report and systematic review

2020 ◽  
Vol 194 ◽  
pp. 105944 ◽  
Author(s):  
Senne Broekx ◽  
Eveleen Buelens
2016 ◽  
Vol 9 ◽  
pp. CCRep.S39904 ◽  
Author(s):  
Fatehi Elzein ◽  
Nada Albogami ◽  
Mustafa Saad ◽  
Nazik El Tayeb ◽  
Abdullah Alghamdi ◽  
...  

Background Intravesical instillation of Bacillus Calmette–Guérin (BCG) remains a first-line treatment for superficial transitional cell carcinoma of the bladder. Although its use is relatively safe, severe complications such as granulomatous hepatitis, osteomyelitis, pneumonitis, and sepsis occur in few patients. Complications of intravesical instillation of BCG can be local or systemic, with early or late presentation. Case Presentation Here, we report an 88-year-old man who developed fever, rigors, and episodes of syncope following fourth intravesical BCG instillation for the treatment of superficial transitional cell carcinoma of the bladder. Pancytopenia, disseminated intravascular coagulation, ground glass appearance on computerized tomography of the chest scan in addition to multiple bone marrow granulomas, suggested the diagnosis of disseminated BCG infection. All these features recovered on antituberculosis treatment. Conclusion Our case study highlights the importance of early recognition and prompt treatment of patients with disseminated BCG infection following intravesical instillation. Although isolation of mycobacterium is desirable to make the diagnosis, it is not unusual to have negative smears and cultures and this should not be used to dismiss the possibility of BCG infection.


2013 ◽  
Vol 91 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Andreas Bourdoumis ◽  
Imran Syed ◽  
Geraldine Soosay ◽  
Ahmed Manzoor ◽  
Jayanta Barua

Urology ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Joseph E. Spirnak ◽  
William L. Lubke ◽  
Ian M. Thompson ◽  
Milagros Lopez

2019 ◽  
Vol 55 ◽  
pp. 168-170
Author(s):  
Ryuichi Taketomi ◽  
Naoto Ujiie ◽  
Yoshitaka Enomoto ◽  
Naruhito Takido ◽  
Yasushi Kawaharada ◽  
...  

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