T46. Correlates of motor disability and fatigue with alterations of cortical excitability and quantitative MRI parameters in relapsing remitting multiple sclerosis and neuromyelitis optica

2018 ◽  
Vol 129 ◽  
pp. e19
Author(s):  
Lk. Sreevidya ◽  
M. Netravathi ◽  
Pramod K. Pal
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Cortical Excitability ◽  
Quantitative Mri ◽  
Motor Disability ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis

2000 ◽  
Vol 6 (5) ◽  
pp. 332-337 ◽  
Author(s):  
T L Luks ◽  
D E Goodkin ◽  
S J Nelson ◽  
S Majumdar ◽  
P Bacchetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Baseline Level ◽  
Disease Duration ◽  
Ventricular Volume ◽  
Quantitative Mri ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Monthly Change

The specific aim of this study was to determine whether progressive brain atrophy could be detected within 18 months of establishing a diagnosis of relapsing-remitting multiple sclerosis (RRMS). Fifteen patients with clinically definite RRMS (mean disease duration from first symptom=6 months, mean EDSS=1.2) completed 6-14 monthly quantitative MRI sessions. The volume of the lateral ventricles was determined each month using a semi-automated thresholding technique from T1-weighted axial images. The number of new monthly gadolinium-enhancing (Gd+) lesions and EDSS scores were also recorded. Lateral ventricular volumes increased significantly during this study. When individual data were examined, statistically significant changes were observed in six of 15 patients. Monthly change in ventricular volume was related to baseline EDSS and total number of new Gd+ lesions. These observations indicate brain atrophy, a putative imaging marker of diffuse demyelination and axonal loss, can occur as early as 18 months after first symptons of RRMS, and is related to the baseline level of disability and to the number of new Gd+ lesions.

Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

2016 ◽  
Vol 44 (6) ◽  
pp. 1600-1607 ◽  
Author(s):  
René-Maxime Gracien ◽  
Alina Jurcoane ◽  
Marlies Wagner ◽  
Sarah C. Reitz ◽  
Christoph Mayer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Quantitative Mri ◽  
Cortical Damage ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis

2019 ◽  
Vol 30 (2) ◽  
pp. 1045-1053 ◽  
Author(s):  
Alexandra van Wijnen ◽  
Franca Petrov ◽  
Michelle Maiworm ◽  
Stefan Frisch ◽  
Christian Foerch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Status ◽  
Quantitative Mri ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis
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