Features and outcomes from a retrospective study of 570 hospitalized Chinese patients with drug-induced liver injury

2018 ◽  
Vol 42 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Lili Pang ◽  
Wanna Yang ◽  
Fengqin Hou
Keyword(s):  
Retrospective Study ◽  
Liver Injury ◽  
Chinese Patients ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xu Li ◽  
Hongqin Xu ◽  
Pujun Gao
Keyword(s):  
Retrospective Study ◽  
Liver Injury ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Chinese Patients ◽  
Red Cell ◽  
Cell Distribution ◽  
Drug Induced ◽  
Distribution Width ◽  
Drug Induced Liver Injury

AbstractWe used a retrospective study design to evaluated the predictive value of red cell distribution width (RDW) for drug-induced liver injury (DILI) severity in Chinese patients with liver biopsy to assist with early DILI management. We included 164 DILI patients with complete laboratory information and medical history. We compared outcomes of 36 patients with severe DILI with outcomes of a control group of 128 patients with mild-to-moderate DILI. Multivariate analyses of risk factors for severe liver injury in Chinese patients with DILI revealed an estimated adjusted odds ratio (AOR) (95% CI) of 4.938 (1.088–22.412) in patients with drinking. Risk for serious liver injury was also increased significantly in patients with dyslipidemia [AOR (95% CI) 3.926 (1.282–12.026)], higher serum total bile acid (TBA) levels [AOR (95% CI) 1.014 (1.009–1.020)] and higher RDW [AOR (95% CI) 1.582 (1.261–1.986)]. The result for area under the curve of 0.905 for TBA levels indicated this variable had high diagnostic performance for predicting DILI severity. Based on an area under the curve value of 0.855, RDW also had superior diagnostic performance in prediction of DILI severity. This performance was not significantly different compared with TBA and was superior compared with other variables, which had area under values ranging from poor to failure (0.527–0.714).The risk for severe DILI was associated with drinking, dyslipidemia, higher TBA levels and RDW values. This study found that RDW and TBA levels were predictors of DILI severity in Chinese patients.

Mo1812 Drug-Induced Liver Injury: A Clinicopathologic Study of 380 Chinese Patients

2014 ◽  
Vol 146 (5) ◽  
pp. S-1001
Author(s):  
Ting Zhang ◽  
Xiao-Ying Teng ◽  
Peng Wang ◽  
Yan-Bin Wang ◽  
Jie Yan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Chinese Patients ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Clinicopathologic Study

Drug-induced liver injury: A 2-year retrospective study of 1169 hospitalized patients in a single medical center

Phytomedicine ◽  
2015 ◽  
Vol 22 (13) ◽  
pp. 1201-1205 ◽  
Author(s):  
Hong Jung Woo ◽  
Ha Yeon Kim ◽  
Eun Sol Choi ◽  
Young-hwan Cho ◽  
Youngchul Kim ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Liver Injury ◽  
Medical Center ◽  
Hospitalized Patients ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Aula Abbara ◽  
Sarah Chitty ◽  
Jennifer K. Roe ◽  
Rohma Ghani ◽  
Simon M. Collin ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Antituberculous Treatment ◽  
The Uk

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

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