Liver and kidney function in refractory heart failure: The narrow gate to achieve post-transplant survival

The acute demise of stem cells following transplantation significantly compromises the efficacy of stem cell-based cell therapeutics for infarcted hearts. As the stem cells transplanted into the damaged heart are readily exposed to the hostile environment, it can be assumed that the acute death of the transplanted stem cells is also inflicted by the same environmental cues that caused massive death of the host cardiac cells. Pyroptosis, a highly inflammatory form of programmed cell death, has been added to the list of important cell death mechanisms in the damaged heart. However, unlike the well-established cell death mechanisms such as necrosis or apoptosis, the exact role and significance of pyroptosis in the acute death of transplanted stem cells have not been explored in depth. In the present study, we found that M1 macrophages mediate the pyroptosis in the ischemia/reperfusion (I/R) injured hearts and identified miRNA-762 as an important regulator of interleukin 1b production and subsequent pyroptosis. Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury. Our data strongly suggest that suppressing pyroptosis can be an effective adjuvant strategy to enhance the efficacy of stem cell-based therapeutics for diseased hearts.

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USE OF METHOTREXATE, WHATEVER KIDNEY FUNCTION, WITH A SIMPLE ALGORITHM, RADICALLY CHANGES THE PROGNOSIS OF POST‐TRANSPLANT CNS LYMPHOMAS

Hematological Oncology ◽

10.1002/hon.72_2880 ◽

2021 ◽

Vol 39 (S2) ◽

Author(s):

S. Choquet ◽

A. Lavaud ◽

I. Boussen ◽

D. Roos‐Weil ◽

V. Morel ◽

...

Keyword(s):

Kidney Function ◽

Simple Algorithm ◽

Post Transplant ◽

Cns Lymphomas

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Hypocalcemic cardiomyopathy after parathyroidectomy in a patient with uremia: A case report and literature review

Journal of International Medical Research ◽

10.1177/0300060520942115 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094211

Author(s):

Wei Zhang ◽

Feng Xue ◽

Quandong Bu ◽

Xuemei Liu

Keyword(s):

Heart Failure ◽

Case Report ◽

Secondary Hyperparathyroidism ◽

Calcium Supplementation ◽

Severe Heart Failure ◽

Cardiac Complications ◽

Refractory Heart Failure ◽

First Case ◽

Insight Into

Hypocalcemia is a rare, but reversible, cause of dilated cardiomyopathy. Although cardiomyopathy may cause severe heart failure, calcium supplementation can reverse heart failure. We report here a patient with uremia and secondary hyperparathyroidism, who was complicated by persistent hypocalcemia and refractory heart failure. The cardiac failure was refractory to treatment with digitalis and diuretics, but dramatically responded to calcium therapy and restoration of normocalcemia. As a result, the patient was eventually diagnosed with hypocalcemic cardiomyopathy. To the best of our knowledge, this is the first case of this disease to be reported in a patient with uremia. Findings from our case may help clinicians to better understand hypocalcemic cardiomyopathy. Our case might also provide new insight into long-term cardiac complications and prognoses of patients undergoing parathyroidectomy due to secondary hyperparathyroidism.

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