Oral clindamycin 300 mg BID compared with oral amoxicillin/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a β-hemolytic streptococci: An international, multicenter, randomized, investigator-blinded, prospective trial in patients between the ages of 12 and 60 years

2006 ◽  
Vol 28 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Prasit Mahakit ◽  
José Gil Vicente ◽  
D. Igbal Butt ◽  
German Angeli ◽  
Sanjay Bansal ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Outpatient Treatment ◽  
Prospective Trial ◽  
Oral Amoxicillin ◽  
Group A ◽  
Amoxicillin Clavulanic Acid ◽  
International Multicenter

scholarly journals Use of Antibiotics in Cleft Palate Post Operative Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 1484-1486
Author(s):  
Mufassar Nishat ◽  
Muhammad Ansar Aslam ◽  
Abid Hussain ◽  
Najaf Abbas ◽  
Usman Ul Haq ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Clavulanic Acid ◽  
Oral Intake ◽  
Wound Dehiscence ◽  
Acid Group ◽  
Oral Amoxicillin ◽  
Group A ◽  
Amoxicillin Clavulanic Acid ◽  
Group B ◽  
Oral Metronidazole

Background: Cleft palate surgeries are one of the most common surgeries done by Plastic surgeons. Aim: To determine the role of postoperative antibiotics in terms of incidence of complications in cleft palate surgery. Study Design: Prospective randomized control trial. Place and duration of study: Department of Plastic Surgery, Bashir Hospital, Sialkot from May 2016 to January 2019 Methodology:. Patients were randomly divided into two groups. Both groups received a single dose of injection Ceftriaxone (50mg/kg) about 30 minutes before incision. Group A (n=25) received a 5-day regimen of oral Amoxicillin + Clavulanic acid (15mg/kg/dose in three divided doses per day) post operatively. Group B (n=25) received 5-day regimen of oral Amoxicillin + Clavulanic acid (15mg/kg/dose in three divided doses per day) plus oral Metronidazole (7.5mg/kg/dose in three divided doses) for 5 days postoperatively. Patients were followed up postoperatively at 2 weeks, 1month and 2 months for complication such as infection and wound dehiscence. Result. .Candidates belonging to Group A, (Amoxicillin + Clavulanic acid group) were reported to have Infection 6 (24%) (P 0.005) and delay oral intake. Candidates who were administered oral Amoxicillin + Clavulanic acid (15mg/kg/dose in three divided doses per day) plus oral Metronidazole (7.5mg/kg/dose in three divided doses) 2 patients (8%) had infection in group B which was settled with improvement in oral hygiene. Conclusion: whose candidates who were admitted or stayed for longer duration of time in hospital had insufficient and poor dietary intake. One of the candidates was again admitted due to being dehydrated along with rotavirus whereas group A 24% patients got infected on the other end group B only 8% patients got infected.In net shell, this study revealed that use of postoperative antibiotics (Amoxicillin + Clavulanic acid and metronidazole) can reduce the incidence of infection and results in better surgical outcome of cleft palate surgery Keywords: cleft palate repair, Amoxicillin, Clavulanic acid, Metronidazole, Prophylactic Antibiotics

Topical Ciprofloxacin/Dexamethasone Found Superior to Oral Amoxicillin/Clavulanic Acid in Acute Otitis Media with Otorrhea

2005 ◽  
Vol 133 (2) ◽  
pp. P127-P127
Author(s):  
J DOHAR ◽  
M WALL ◽  
P ROLAND ◽  
S DUPRE ◽  
S POTTS ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Oral Amoxicillin ◽  
Amoxicillin Clavulanic Acid

scholarly journals Emergence of Resistance in Normal Human Aerobic Commensal Flora during Telithromycin and Amoxicillin-Clavulanic Acid Treatments

2003 ◽  
Vol 47 (6) ◽  
pp. 2030-2035 ◽  
Author(s):  
Anne-Claude Crémieux ◽  
Claudette Muller-Serieys ◽  
Xavière Panhard ◽  
Frédérique Delatour ◽  
Marina Tchimichkian ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Coagulase Negative Staphylococci ◽  
Once Daily ◽  
Commensal Flora ◽  
Human Volunteers ◽  
Group A ◽  
Amoxicillin Clavulanic Acid ◽  
Normal Human ◽  
Emergence Of Resistance ◽  
Acid Treatments

ABSTRACT Mean fecal global yeast counts increased similarly during 7 days of treatment with telithromycin (800 mg once daily) or amoxicillin-clavulanic acid (amoxiclav) (1 g of amoxicillin and 125 mg of clavulanic acid 3 times daily) in human volunteers and decreased slowly thereafter. On skin, coagulase-negative staphylococci of decreased susceptibility (DS) to telithromycin increased in the telithromycin group, whereas those with DS to methicillin increased in the amoxiclav group. A similar antibiotic-related shift towards homologous DS was observed for oral nongroupable streptococci (NGS), but in addition, the prevalence of NGS resistant to both classes of antibiotics was significantly greater in the amoxiclav group at days 8 (P < 0.01) and 45 (P < 0.015).

Comparison of adherence between twice- and thrice-daily regimens of oral amoxicillin/clavulanic acid

Respirology ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 687-692 ◽  
Author(s):  
CARL LLOR ◽  
CAROLINA BAYONA ◽  
SILVIA HERNÁNDEZ ◽  
ANA MORAGAS ◽  
MARC MIRAVITLLES
Keyword(s):  
Clavulanic Acid ◽  
Oral Amoxicillin ◽  
Amoxicillin Clavulanic Acid

scholarly journals Efficacy of amoxicillin-clavulanic acid versus ceftriaxone in children hospitalized under 5 years of age with uncomplicated community acquired pneumonia.

2020 ◽  
Vol 27 (11) ◽  
pp. 2339-2344
Author(s):  
Huriya Abid ◽  
Wajiha Rizwan ◽  
Irfan Naeem ◽  
Aysha Mansoor Lodhi ◽  
Muhammad Nasir Rana
Keyword(s):  
Clavulanic Acid ◽  
Controlled Trial ◽  
Community Acquired Pneumonia ◽  
Duration Of Symptoms ◽  
Treatment Groups ◽  
Acid Versus ◽  
Group A ◽  
Amoxicillin Clavulanic Acid ◽  
Group B ◽  
Children Under 5

Objectives: Community acquired pneumonia (CAP) is considered to be the commonest reason for hospitalization among children. Pneumonia is the leading cause of mortality among children in Pakistan in children, causing 33% of all deaths in infants and 37% of all deaths in children 1 to 4 years. The aim of current study was to compare efficacy of amoxicillin-clavulanic acid versus ceftriaxone among children under 5 years of age, hospitalized having uncomplicated CAP. Study Design: Randomized Controlled trial (RCT). Setting: Department of Pediatric Medicine, The Children Hospital and Institute of Child Health, Lahore. Period: 01/01/2019 to 30/06/2019. Material & Methods: A total of 210 (105 in each group) children aged between 2 to 60 months, diagnosed having CAP were randomly allocated into either Group-A (received IV amoxicillin-clavulanic acid) or Group B (received IV ceftriaxone). Efficacy in terms of response of both treatment groups was noted after 5 days treatment. Results: Overall, mean age was noted as 14.68±15.7 months. Majority (n=131, 32.4%) were male and aged between 1 to 12 months (n=135, 64.3%). Mean duration of symptoms was noted as 3.60±1.69 days. Efficacy was significantly higher in children treated with ceftriaxone as compared to those treated with Amoxicillin/Clavulanic acid (96.2% vs. 76.2%; p<0.001). This difference was significant across all age, gender and duration of symptom groups (p<0.05). Conclusion: The efficacy was significantly higher in children treated with ceftriaxone as compared to Amoxicillin/Clavulanic acid.

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