Full results of the Evidence of Interferon Dose-Response-European North American Comparative Efficacy (EVIDENCE) study: A multicenter, randomized, assessor-blinded comparison of low-dose weekly versus high-dose, high-frequency interferon β-1a for relapsing multiple sclerosis

2007 ◽  
Vol 29 (9) ◽  
pp. 2031-2048 ◽  
Author(s):  
S SCHWID ◽  
H PANITCH
Keyword(s):  
Multiple Sclerosis ◽  
Dose Response ◽  
North American ◽  
High Frequency ◽  
Low Dose ◽  
High Dose ◽  
Interferon Β ◽  
Comparative Efficacy ◽  
European North ◽  
Relapsing Multiple Sclerosis

scholarly journals Enrollment in a Multiple Sclerosis Clinical Trial: The EVIDENCE Experience

2004 ◽  
Vol 6 (1) ◽  
pp. 23-25
Author(s):  
Edward Monaghan ◽  
Marylou Basile ◽  
Olympia Hadjimichael ◽  
Timothy L. Vollmer ◽  
Gordon S. Francis
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Web Sites ◽  
North American ◽  
Dose Effect ◽  
Efficacy Study ◽  
Comparative Efficacy ◽  
Successful Recruitment ◽  
European North ◽  
Bulletin Boards

This paper describes the methods used to recruit patients for the EVIDENCE (EVidence for Interferon Dose-Effect: European-North American Comparative Efficacy) study, and the results of that recruitment. The majority of enrolled patients came from the investigators' clinic populations, with an additional 30% entering the study as a result of specific recruitment efforts. Local efforts, including referrals from colleagues, postings on bulletin boards, contacts with local Multiple Sclerosis Society chapters and newspaper advertisements, were the most successful recruitment tools. Mass mailings to local neurologists, referrals from a national multiple sclerosis registry, Web sites, and radio or television spots were less effective in recruiting eligible patients.

Amelioration of flulike symptoms at the onset of interferon β- 1b therapy in multiple sclerosis by low-dose oral steroids is related to a decrease in interleukin-6 induction

1998 ◽  
Vol 44 (4) ◽  
pp. 682-685 ◽  
Author(s):  
E. M. MartíNez-CáCeres ◽  
J. Río ◽  
M. Barrau ◽  
I. Durán ◽  
C. Borrás ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interleukin 6 ◽  
Low Dose ◽  
Interferon Β ◽  
Oral Steroids ◽  
Dose Oral

scholarly journals New natural history of interferon-β-treated relapsing multiple sclerosis

2007 ◽  
Vol 61 (4) ◽  
pp. 300-306 ◽  
Author(s):  
Maria Trojano ◽  
Fabio Pellegrini ◽  
Aurora Fuiani ◽  
Damiano Paolicelli ◽  
Valentina Zipoli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Natural History ◽  
Interferon Β ◽  
History Of ◽  
Relapsing Multiple Sclerosis
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