efficacy study
Recently Published Documents


TOTAL DOCUMENTS

929
(FIVE YEARS 234)

H-INDEX

56
(FIVE YEARS 5)

Author(s):  
Abhijitsinh Parmar ◽  
Dixit Patel ◽  
Parvathy Hari ◽  
Rajesh Babu ◽  
Prasenjit Maity

Author(s):  
Colleen M. Leonard ◽  
Hussein Mohammed ◽  
Mekonnen Tadesse ◽  
Jessica N. McCaffery ◽  
Doug Nace ◽  
...  

Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia. This study investigated whether mixed infections were missed by microscopy from a 2017 therapeutic efficacy study at two health facilities in Ethiopia. All patients (N = 304) were initially classified as having single-species P. falciparum (n = 148 samples) or P. vivax infections (n = 156). Dried blood spots were tested for Plasmodium antigens by bead-based multiplex assay for pan-Plasmodium aldolase, pan-Plasmodium lactate dehydrogenase, P. vivax lactate dehydrogenase, and histidine-rich protein 2. Of 304 blood samples, 13 (4.3%) contained both P. falciparum and P. vivax antigens and were analyzed by polymerase chain reaction for species-specific DNA. Of these 13 samples, five were confirmed by polymerase chain reaction for P. falciparum/P. vivax co-infection. One sample, initially classified as P. vivax by microscopy, was found to only have Plasmodium ovale DNA. Plasmodium falciparum/P. vivax mixed infections can be missed by microscopy even in the context of a therapeutic efficacy study with multiple trained readers.


Author(s):  
Jespher Nyaboke Onyango ◽  
Dr. Jackson Odhiambo Onyuka ◽  
Jared Misonge Onyancha ◽  
Patrick Ogembo Getonto.

Sign in / Sign up

Export Citation Format

Share Document