Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: An open-label, prospective study of long-term administration in adults

2010 ◽  
Vol 32 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Mordechai Muszkat ◽  
Omer Bialer ◽  
Simcha Blotnick ◽  
Liat Adar ◽  
Hong-Guang Xie ◽  
...  
Keyword(s):  
Folic Acid ◽  
Prospective Study ◽  
Folic Acid Supplementation ◽  
Anticoagulant Effect ◽  
Open Label ◽  
Acid Supplementation ◽  
Term Administration

scholarly journals The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)

2018 ◽  
Vol 47 (3) ◽  
pp. 928-937 ◽  
Author(s):  
Rebecca C Richmond ◽  
Gemma C Sharp ◽  
Georgia Herbert ◽  
Charlotte Atkinson ◽  
Caroline Taylor ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Long Term Impact ◽  
In Pregnancy

Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy

2018 ◽  
Vol 85 (7) ◽  
pp. 493-497 ◽  
Author(s):  
Bindu Deopa ◽  
Manish Parakh ◽  
Pawan Dara ◽  
Vikas Payal ◽  
Kapil Chordiya ◽  
...  
Keyword(s):  
Folic Acid ◽  
Seizure Control ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Antiepileptic Therapy ◽  
Epileptic Children

scholarly journals Effect of long-term low-dose folic acid supplementation on degree of total homocysteine-lowering: major effect modifiers

2018 ◽  
Vol 120 (10) ◽  
pp. 1122-1130 ◽  
Author(s):  
Binyan Wang ◽  
Hongxu Wu ◽  
Youbao Li ◽  
Qianyun Ban ◽  
Xiao Huang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Smoking Status ◽  
Folic Acid Supplementation ◽  
Major Effect ◽  
Acid Supplementation ◽  
Total Homocysteine ◽  
Using Data

AbstractWe sought to examine the potential modifiers in the association between long-term low-dose folic acid supplementation and the reduction of serum total homocysteine (tHcy) among hypertensive patients, using data from the China Stroke Primary Prevention Trial (CSPPT). This analysis included 16 867 participants who had complete data on tHcy measurements at both the baseline and exit visit. After a median treatment period of 4·5 years, folic acid treatment significantly reduced the tHcy levels by 1·6 μmol/l (95 % CI 1·4, 1·8). More importantly, after adjustment for baseline tHcy and other important covariates, a greater degree of tHcy reduction was observed in certain subgroups: males, the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype, higher baseline tHcy levels (≥12·5 (median) v. <12·5 μmol/l), lower folate levels (<8·0 (median) v. ≥8·0 ng/ml), estimated glomerular filtration rate (eGFR) <60 ml/min per 1·73 m2 (v. 60–<90 and ≥90 ml/min per 1·73 m2), ever smokers and concomitant use of diuretics (P for all interactions <0·05). The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status.

Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation

2002 ◽  
Vol 112 (7) ◽  
pp. 535-539 ◽  
Author(s):  
Kam S Woo ◽  
Ping Chook ◽  
Lindy L.T Chan ◽  
Alice S.P Cheung ◽  
Wing H Fung ◽  
...  
Keyword(s):  
Folic Acid ◽  
Endothelial Function ◽  
Folic Acid Supplementation ◽  
Acid Supplementation
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