Preconception Steroid Treatment in Infertile Women with Antithyroid Autoimmunity Undergoing Ovarian Stimulation and Intrauterine Insemination: A Double-Blind, Randomized, Prospective Cohort Study

2010 ◽  
Vol 32 (14) ◽  
pp. 2415-2421 ◽  
Author(s):  
Angelo Turi ◽  
Stefano Raffaele Giannubilo ◽  
Sara Zanconi ◽  
Alessandra Mascetti ◽  
Andrea Luigi Tranquilli
2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Norbert Gleicher ◽  
Andrea Weghofer ◽  
Sarah K. Darmon ◽  
David H. Barad

AbstractPreviously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, for a so-called rebound response to ovarian stimulation. A rebound response was defined as follicle growth following complete withdrawal of exogenous gonadotropin stimulation after complete failure to respond to maximal gonadotropin stimulation over up to 5–7 days. Median age of study patients was 40.5 ± 5.1 years (range 23–52). Women with and without rebound did not differ significantly (40.0 ± 6.0 vs. 41.0 ± 7.0 years, P = 0.41), with 24 (49.0%) recording a rebound and 25 (51.0%) not. Among the former, 21 (87.5%) reached retrieval of 1–3 oocytes and 15 (30.6%) reached embryo transfer. A successful rebound in almost half of prior non-responders was an unsuspected response rate, as was retrieval of 1–3 oocytes in over half of rebounding patients. Attempting rebounds may, thus, represent another incremental step in very poor prognosis patients before giving up on utilization of autologous oocytes. Here presented findings support further investigations into the underlying physiology leading to such an unexpectedly high rebound rate.


2018 ◽  
Vol 109 (5) ◽  
pp. 872-878 ◽  
Author(s):  
Shuo Huang ◽  
Rui Wang ◽  
Rong Li ◽  
Haiyan Wang ◽  
Jie Qiao ◽  
...  

1993 ◽  
Vol 9 (1) ◽  
pp. 139-144 ◽  
Author(s):  
James E. Groves ◽  
Philip W. Lavori ◽  
Jerrold F. Rosenbaum

AbstractEight hundred and six medical and surgical patients who were hospitalized via the emergency ward were followed over their entire inpatient stays and rated in anterograde, double-blind fashion for inpatient incidents (falls, medication errors, other). Injuries were minor but affected 2.2% of admissions, a figure which is strikingly similar to studies in other hospitals. There was a statistical trend toward a higher-than-normal risk of hazardous in-hospital incidents for males age 20 to 40 admitted because of injury and for medically ill females over 60 years old.


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