Effect of Some Prostanoids Modulators and Cyclooxygenase Inhibitors on Rat Bladder Detrusor Muscle in Normal and Cyclophosphamide- Induced Cystitis

Diabetic bladder dysfunction (DBD) is among the most common and bothersome complications of diabetes mellitus. Autonomic neuropathy has been counted as the cause of DBD. In the present study, we compared the alterations in the neurogenically mediated contractile responses of urinary bladder in rats with streptozocin-induced diabetes, 5% sucrose-induced diuresis, and age-matched controls. Male Sprague-Dawley rats were divided into three groups: 9-wk diabetic rats, diuretic rats, and age-matched controls. Micturition and morphometric characteristics were evaluated using metabolic cage and gross examination of the bladder. Bladder detrusor muscle strips were exposed to either periodic electrical field stimulation (EFS) or to EFS in the presence of atropine, α,β-methylene adrenasine 5′-triphosphate, or tetrodotoxin. The proportions of cholinergic, purinergic, and residual nonadrenergic-noncholinergic (NANC) components of contractile response were compared among the three groups of animals. Diabetes caused a significant reduction of body weight compared with diuresis and controls, although the bladders of diabetic and diuretic rats weighed more than the controls. Both diabetes and diuresis caused significant increase in fluid intake, urine output, and bladder size. Diabetes and diuresis caused similarly increased response to EFS and reduced response to cholinergic component compared with controls. However, the purinergic response was significantly smaller in diuretic bladder strips compared with controls but not in diabetic rats. A residual NANC of unknown origin increased significantly but differently in diabetics and diuretics compared with controls. In conclusion, neurogenically mediated bladder contraction is altered in the diabetic rat. Diabetic-related changes do not parallel diuretic-induced changes, indicating that the pathogenesis of DBD needs further exploration.

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Role of Calcium Ion Antagonists of the Bladder Detrusor Muscle: In Vitro and in Vivo Study

The Journal of Urology ◽

10.1016/s0022-5347(17)46085-x ◽

1986 ◽

Vol 135 (6) ◽

pp. 1327-1331 ◽

Cited By ~ 13

Author(s):

M. Hassouna ◽

O. Nishizawa ◽

I. Miyagawa ◽

A. Toguri ◽

M. Gotoh ◽

...

Keyword(s):

Calcium Ion ◽

In Vivo Study ◽

Detrusor Muscle ◽

Bladder Detrusor

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MP28-09 A NOVEL MODEL OF PELVIC ORGAN ISCHEMIA: PELVIC FLOOR CONTRACTILE FUNCTION IS MORE RESISTANT TO ISCHEMIA AND POST-ISCHEMIA REPERFUSION THAN BLADDER DETRUSOR MUSCLE

The Journal of Urology ◽

10.1016/j.juro.2016.02.1059 ◽

2016 ◽

Vol 195 (4S) ◽

Author(s):

Amy D. Dobberfuhl ◽

Catherine Schuler ◽

Robert E. Leggett ◽

Elise J.B. De ◽

Robert M. Levin

Keyword(s):

Pelvic Floor ◽

Contractile Function ◽

Ischemia Reperfusion ◽

Pelvic Organ ◽

Detrusor Muscle ◽

Bladder Detrusor ◽

Novel Model

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Selective sacral rootlet rhizotomy for hypertonic neurogenic bladder

Journal of Neurosurgery ◽

10.3171/jns.1975.42.5.0567 ◽

1975 ◽

Vol 42 (5) ◽

pp. 567-574 ◽

Cited By ~ 33

Author(s):

Stanislaw K. Toczek ◽

David C. McCullough ◽

Guy W. Gargour ◽

Rudolf Kachman ◽

Roger Baker ◽

...

Keyword(s):

Neurogenic Bladder ◽

Conus Medullaris ◽

Physiological Data ◽

Detrusor Muscle ◽

Lower Extremity Function ◽

Accurate Identification ◽

Content Type ◽

Alternative Pathways ◽

Bladder Detrusor ◽

Stimulation Of

✓ The authors describe a highly selective transsacral microsurgical procedure for sacral nerve rootlet interruption in five patients with hypertonic neurogenic bladder. Magnification and systematic stimulation of sacral roots provided accurate identification of motor fibers supplying bladder detrusor muscle and differentiation of efferent components to the legs and anal sphincter. Although the technique prevented incontinence and adverse effects of nerve section on rectal and lower extremity function, improvement in voiding patterns and diminution of urinary sepsis was of brief duration in three of the five patients. Physiological data from these procedures reaffirms the importance of S-3 and S-4 motor roots in detrusor innervation, but clinical responses bring into question the possibility of sustained improvement from such a highly selective procedure at the sacral level. The authors suggest that alternative pathways, not apparent on initial stimulation, may develop after section of sacral root components, and that dissection and stimulation of fibers at the level of the conus medullaris should be investigated as an alternative procedure.

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CLINICAL AND EXPERIMENTAL STUDIES ON THE BLADDER DETRUSOR MUSCLE

The Japanese Journal of Urology ◽

10.5980/jpnjurol1928.68.6_553 ◽

1977 ◽

Vol 68 (6) ◽

pp. 553-568

Author(s):

Yasuhiko Onoye

Keyword(s):

Experimental Studies ◽

Detrusor Muscle ◽

Bladder Detrusor

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Safety and efficacy of en bloc transurethral resection versus conventional transurethral resection for primary nonmuscle-invasive bladder cancer: a meta-analysis

World Journal of Surgical Oncology ◽

10.1186/s12957-019-1776-4 ◽

2020 ◽

Vol 18 (1) ◽

Cited By ~ 4

Author(s):

Dong Zhang ◽

Lifeng Yao ◽

Sui Yu ◽

Yue Cheng ◽

Junhui Jiang ◽

...

Keyword(s):

Recurrence Rate ◽

Transurethral Resection ◽

Bladder Tumor ◽

Meta Analysis ◽

Residual Tumor ◽

Detrusor Muscle ◽

En Bloc ◽

Safety And Efficacy ◽

Significant Difference ◽

Bladder Detrusor

Abstract Background The purpose of this meta-analysis is to compare the safety and efficacy of en bloc transurethral resection of bladder tumor (EBRT) versus conventional transurethral resection of bladder tumor (CTURBT). Methods We performed a meta-analysis of relevant articles through November 2019 using PubMed, Embase, and Cochrane Central Register to compare the safety and efficacy of EBRT versus CTURBT. The main endpoint included the operation time (OT), hospitalization time (HT), catheterization time (AT), perioperative period complications, bladder detrusor muscle found in the specimen, the residual tumor on the base, the ratio of the same site recurrence, and 12/24/36-month recurrence rate. Cochrane Collaboration’s Revman software, version 5.3, was used for statistical analysis. Results A total of 19 studies with 2651 patients were included, 1369 underwent EBRT and 1282 underwent CTURBT. Patients treated with EBRT had a significantly lower AT, HT, obturator nerve reflex, bladder perforation, bladder irritation, postoperative complications, and 24-month recurrence rate than those who underwent CTURBT. While no significant difference was found in terms of OT, the ratio of bladder detrusor muscle found in the specimen, the residual tumor on the base, 12-month recurrence rate, 36-month recurrence rate, and the ratio of the same site recurrence. In mitomycin subgroup, EBRT was superior to CTURBT in terms of 12/24-month recurrence rate. Similarly, in the prospective subgroup and retrospective subgroup, EBRT had a lower 24-month recurrence rate than CTURBT. However, no significant difference was found in the low, intermediate, and high-risk group in the light of 12–36-month recurrence rate. Conclusions Based on the included 19 articles, EBRT had a significantly lower AT, HT, intraoperative and postoperative complications, and 24-month recurrence rate than those treated with CTURBT. Well-designed randomized controlled trials were needed to reevaluate these outcomes. Trial registration This meta-analysis was reported in agreement with the PRISMA statement and was registered on PROSPERO 2019 CRD42019121673.

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