Disseminated Cryptococcal infection in an immunocompetent host mimicking plasma cell disorder: a case report and literature review

2015 ◽  
Vol 15 ◽  
pp. e208-e209 ◽  
Author(s):  
M.B. Abid ◽  
S. De Mel ◽  
M.P. Limei
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Plasma Cell ◽  
Immunocompetent Host ◽  
Cryptococcal Infection ◽  
Plasma Cell Disorder ◽  
Cell Disorder

scholarly journals A Rare Case of Nonsecretory Multiple Myeloma in Lagos, Nigeria: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ebele Uche ◽  
Akinsegun Akinbami ◽  
Sarah John-Olabode ◽  
Adedoyin Dosunmu ◽  
Majeed Odesanya
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Literature Review ◽  
Plasma Cells ◽  
Diagnostic Challenge ◽  
Medical Practitioners ◽  
Bone Marrow Trephine Biopsy ◽  
Clonal Proliferation ◽  
Plasma Cell Disorder ◽  
Cell Disorder

Multiple myeloma (MM) is a plasma cell disorder associated with clonal proliferation of plasma cells. Nonsecretory multiple myeloma (NSMM) is a rare variant of MM and accounts for approximately 1% to 5% of all cases. It is defined as symptomatic myeloma without detectable monoclonal immunoglobulin on serum or urine electrophoresis. This variant usually poses a diagnostic challenge to the clinician. We present a 60-year-old Nigerian man who was investigated extensively for bone pain, weight loss, and anaemia. He was eventually diagnosed as having nonsecretory multiple myeloma based on histology and immunohistochemistry results of bone marrow trephine biopsy. He is currently being managed with bortezomib, doxorubicin, and thalidomide, as well as zoledronic acid. He is also on anticoagulation. He continues to show remarkable clinical improvement. We describe this case report and literature review for better awareness amongst medical practitioners and pathologists.

Supraglottic immunoglobulin-G4 related plasma cell granuloma: Case report and literature review

Head & Neck ◽  
2014 ◽  
Vol 36 (6) ◽  
pp. E57-E59 ◽  
Author(s):  
Jeremy F. Khoo ◽  
Michael Batt ◽  
Paul Stimpson ◽  
Adnan Safdar
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Plasma Cell ◽  
Plasma Cell Granuloma ◽  
Immunoglobulin G4

scholarly journals Mycobacterium triplex pulmonary disease in an immunocompetent host: A case report and literature review

IDCases ◽  
2019 ◽  
Vol 18 ◽  
pp. e00648
Author(s):  
Masahiro Shirata ◽  
Aki Tamaru ◽  
Satoshi Marumo ◽  
Motonari Fukui
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Pulmonary Disease ◽  
Immunocompetent Host

Sjögren syndrome-related plasma cell disorder and multifocal nodular AL amyloidosis: clinical picture and pathological findings

Amyloid ◽  
2019 ◽  
Vol 26 (4) ◽  
pp. 225-233 ◽  
Author(s):  
Shu-ichi Ikeda ◽  
Akiyo Hineno ◽  
Tsuneaki Yoshinaga ◽  
Kiyoshi Matsuo ◽  
Tomoaki Suga ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Clinical Picture ◽  
Sjögren Syndrome ◽  
Al Amyloidosis ◽  
Sjogren Syndrome ◽  
Pathological Findings ◽  
Plasma Cell Disorder ◽  
Cell Disorder

Fluorescence In Situ Hybridization Studies in 22 Cases of Plasma Cell Leukemia.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4461-4461
Author(s):  
Jianyong Li ◽  
Wei Xu ◽  
Lijuan Chen ◽  
Yu Zhu ◽  
Jinlan Pan ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Plasma Cell ◽  
Cell Leukemia ◽  
Molecular Cytogenetic ◽  
Cytogenetic Aberrations ◽  
Plasma Cell Disorder ◽  
Igh Rearrangement ◽  
Cell Disorder

Abstract Background Plasma cell leukemia (PCL) is a rare malignant plasma cell disorder that usually carries an aggressive course with a rapidly fatal outcome. Cytogenetic studies performed on plasma cell disorder are scarce and difficult because of the low proliferation rate of plasma cells. Fluorescence in situ hybridization (FISH) analysis is an attractive alternative for evaluation of numerical and structural chromosomal changes in PCL. Methods Interphase FISH (I-FISH) and two different specific probes for the regions containing 13q14.3 (D13S319) or 14q32 (IGHC/IGHV) were used to detect 13q14 deletion [del(13q14)] or IgH rearrangement in 22 PCL patients. For patients with IgH rearrangement, probes for IgH(JH) and 11q13 (CCND1) or 4p16 (FGFR3) were used to detect t(11;14)(q13;q32) or t(4;14)(p16;q32). Results Molecular cytogenetic aberrations were found in 19 of 22 (86.4%) PCL patients. Del(13q14) was detected in 13 cases (59.1%), and IgH rearrangement in 17 (77.3%) patients including 7 with t(11;14) and 3 with t(4;14). 14q32 rearrangement and 13q14 deletion were found concurrently in 11 cases (50%). Conclusions Chromosomal abnormalities are frequent in PCL. The most frequent aberrations among the cases was the 14q32 rearrangement and 13q14 deletion. I-FISH technique is useful to detect molecular cytogenetic aberrations and should be used in the routine evaluation of PCL.

t(11;14) Plasma Cell Disorder Presents as a True Nonsecretory, Nonproducer Multiple Myeloma

2009 ◽  
Vol 9 (3) ◽  
pp. 243-246 ◽  
Author(s):  
Wei Chen ◽  
Mark McNamara ◽  
Young Kim ◽  
Qin Huang
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cell ◽  
Plasma Cell Disorder ◽  
Cell Disorder
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