The effect of l-carnitine supplementation on lipid profile and glycaemic control in adults with cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials

2020 ◽  
Vol 39 (1) ◽  
pp. 110-122 ◽  
Author(s):  
Maryam Asadi ◽  
Mehran Rahimlou ◽  
Farideh Shishehbor ◽  
Anahita Mansoori
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Clinical Trials ◽  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Meta Analysis ◽  
Carnitine Supplementation ◽  
Controlled Clinical Trials ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled

The Effect of Anethum Graveolens L. (Dill) on Lipid Profile in Adults with Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Controlled Clinical Trials

2021 ◽  
Author(s):  
Anahita Mansoori ◽  
Zahra Salimi ◽  
Seyyed Ahmad Hosseini ◽  
Razie Hormoznejad ◽  
Maryam Asadi
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Clinical Trials ◽  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Cardiovascular Risk Factors ◽  
Meta Analysis ◽  
Controlled Clinical Trials ◽  
Anethum Graveolens ◽  
Randomized Controlled

Background: Several randomized clinical trials (RCTs) has assessed the effect of Anethum graveolens L. (AG) or dill supplementation on lipid profile in adults with cardiovascular risk factors with different results. Therefore, we decided to conduct a systematic review and meta-analysis regarding the available randomized controlled trials to assess AG supplementation's efficacy on lipid profile in adults with cardiovascular risk factors. Methods: PubMed, Embase, Cochrane's database, Ovid, Web of Science, ProQuest, Scopus, and Google Scholar were searched to find relevant articles investigating the effect of AG on the lipid profile of adults with risk factors for cardiovascular disease up to December 2020. Six trials with seven treatment armsmet the inclusion criteria. A random-effects model was used in the meta-analysis. To test heterogeneity, I2 statistics and Cochrane Q test were applied. Results: The results reported a significant improving effect of AG on TG [WMD = -29.20, 95% confidence interval (CI): -34.73,-23.68 mg/dL, p < 0.001], TC (WMD = -16.46, 95%CI: -21.54,-11.39 mg/dL, p < 0.001), LDL-C (WMD = -13.90, 95%CI: -16.08, -11.72 mg/dL, p < 0.001), and HDL-C (WMD = 4.01, 95%CI: 3.48, 4.54 mg/dL, p < 0.001). Conclusion: This meta-analysis of randomized controlled clinical trials revealed that consuming AG extract for more than six weeks might improve lipid profile in adults with cardiovascular risk factors.

Effects of cinnamon supplementation on systolic and diastolic blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials

2021 ◽  
Author(s):  
Zeinab Yazdanpanah ◽  
Mandana Amiri ◽  
Azadeh Nadjarzadeh ◽  
Hadis Hooshmandi ◽  
Maryam Azadi-Yazdi
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Clinical Trials ◽  
Diastolic Blood Pressure ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Controlled Clinical Trials ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled

Introduction: Hypertension is a chronic condition that might lead to renal and cardiovascular diseases. The previous trials examining the effect of cinnamon supplementation on blood pressure have led to conflicting results. The present systematic review aimed to summarize the effect of cinnamon supplementation on blood pressure using a meta-analysis of published randomized controlled clinical trials. Methods: To identify the eligible articles, MEDLINE, SCOPUS, ISI Web of Science, and Google Scholar were searched from inception until September 2019 for relevant articles. The risk of bias assessment was performed using the Cochrane collaboration tool. A Random-effects model was applied to calculate the summary effects. Results: Totally, 11 trials with 686 participants were included in this systematic review and meta-analysis. The dose of cinnamon supplement consumption varied from 500 to 10000 mg/d. The meta-analysis revealed that cinnamon supplementation significantly decreases systolic blood pressure (SBP) [WMD (weighted mean difference)= -5.72 mmHg, 95% confidence interval (CI): -8.63 to -2.80; P<0.001, I2= 81.1)] and diastolic blood pressure (DBP) (WMD= -4.06 mmHg, 95% CI: -6.68 to -1.44; P= 0.002, I2 = 88.6). Subgroup analysis suggested no significant reduction of DBP in subjects with diabetes (WMD= -2.015 mmHg, 95% CI: -4.55 to 0.52; P= 0.12, I2 = 72.3) and prediabetes or metabolic syndrome (WMD= -4.8 mmHg, 95% CI: -10.06 to 0.44; P= 0.073, I2= 92.5). Conclusions: Cinnamon supplementation could be beneficial in lowering SBP and DBP in adults. Further studies with different doses are recommended to confirm the present findings.

Sign in / Sign up

Export Citation Format

Share Document