Hybrid modeling — a key enabler towards realizing digital twins in biopharma?

2021 ◽  
Vol 34 ◽  
pp. 100715
Author(s):  
Michael Sokolov ◽  
Moritz von Stosch ◽  
Harini Narayanan ◽  
Fabian Feidl ◽  
Alessandro Butté
Author(s):  
V. A. Minaev ◽  
A. V. Mazin ◽  
K. B. Zdiruk ◽  
L. S. Kulikov

The article presents the scientific and methodological issues of formation of digital twins collections based on the use of the multi-aspect recursive decomposition algorithm of the subject area. The general approaches to the solution of topical issues of the modern stage of artificial intelligence are considered. The terminology is concretized in the interrelated areas of knowledge – information – data and its relation with the term of «digital twins» as information containers of knowledge is discussed. The structure, power estimation and metrizability of the information space presented as a recursively defined ordered set of elements – a collection of digital twins (DT-collections) are considered. It is shown that the practical implementation of this approach and its application as part of automated control systems involves maintaining the life cycle of the creation and operation of digital twins in the Integrated information storage, implementing a two-circuit scheme (model) of management. A new cognitive approach to assess the completeness of the knowledge measure in the information space is proposed. The model of the integrated information storage realizing accumulation of knowledge in data banks of primary and secondary information is considered. As an example, a recursive decomposition of a subset of engineering systems of an educational institution is performed.


2020 ◽  
Vol 53 (2) ◽  
pp. 10556-10561
Author(s):  
Chiara Cimino ◽  
Gianni Ferretti ◽  
Alberto Leva
Keyword(s):  

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