Rhodamine-loaded, cross-linked, carboxymethyl cellulose sodium-coated super-paramagnetic iron oxide nanoparticles: Development and in vitro localization study for magnetic drug-targeting applications

2015 ◽  
Vol 481 ◽  
pp. 51-62 ◽  
Author(s):  
Neha Mallick ◽  
Mohammed Asfer ◽  
Mohammed Anwar ◽  
Arun Kumar ◽  
Mohammad Samim ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Carboxymethyl Cellulose ◽  
Drug Targeting ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Localization Study ◽  
Super Paramagnetic Iron Oxide ◽  
Carboxymethyl Cellulose Sodium

Visualization and Motion of Curcumin Loaded Iron Oxide Nanoparticles During Magnetic Drug Targeting

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammed Asfer ◽  
Ayodhya Prasad Prajapati ◽  
Arun Kumar ◽  
Pradipta Kumar Panigrahi
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Applied Magnetic Field ◽  
Drug Targeting ◽  
In Vitro Study ◽  
Target Site ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Magnetic drug targeting (MDT) involves the localization of drug loaded iron oxide nanoparticles (IONPs) around the malignant tissue using external magnetic field for therapeutic purposes. The present in vitro study reports the visualization and motion of curcumin loaded IONPs (CU-IONPs) around the target site inside a microcapillary (500 × 500 μm2 square cross section), in the presence of an externally applied magnetic field. Application of magnetic field leads to transportation and aggregation of CU-IONPs toward the target site inside the capillary adjacent to the magnet. The localization/aggregation of CU-IONPs at the target site shows strong dependence on the strength of the applied magnetic field and flow rate of ferrofluid through the capillary. Such an in vitro study offers a viable for optimization and design of MDT systems for in vivo applications.

Chemically tunable cationic polymer-bonded magnetic nanoparticles for gene magnetofection

2014 ◽  
Vol 2 (6) ◽  
pp. 644-650 ◽  
Author(s):  
Makoto Takafuji ◽  
Kumiko Kitaura ◽  
Takuro Nishiyama ◽  
Srinath Govindarajan ◽  
Vijaya Gopal ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Viral Vectors ◽  
Cationic Polymer ◽  
Oxide Nanoparticles ◽  
Super Paramagnetic Iron Oxide

This study evaluates the efficiency of novel non-viral vectors consisting of super paramagnetic iron oxide nanoparticles functionalized with the chemically tunable cationic polymer forin vitrogene magnetofection.

Molecular composition of iron oxide nanoparticles, precursors for magnetic drug targeting, as characterized by confocal Raman microspectroscopy

The Analyst ◽  
2005 ◽  
Vol 130 (10) ◽  
pp. 1395 ◽  
Author(s):  
Igor Chourpa ◽  
Laurence Douziech-Eyrolles ◽  
Lazare Ngaboni-Okassa ◽  
Jean-François Fouquenet ◽  
Simone Cohen-Jonathan ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Raman Microspectroscopy ◽  
Molecular Composition ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting

2016 ◽  
Vol 101 ◽  
pp. 152-162 ◽  
Author(s):  
Jan Zaloga ◽  
Marina Pöttler ◽  
Gerd Leitinger ◽  
Ralf P. Friedrich ◽  
Gunter Almer ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Pharmaceutical Formulation ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

2016 ◽  
Vol 25 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Mihail Teodorescu ◽  
Adrian Săftoiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review. Abbreviations: AMF: Alternating magnetic field; DOX: Doxorubicin; GD: Gadolinium; HCC: hepatocellular carcinoma; 131I: Iodine 131; MDT: Magnetic drug targeting; ML: Magnetoliposomes; MNP: magnetic nanoparticles; MRI: Magnetic Resonance Imaging; PNIPA: Poly-N-isopropylacrylamide; SPIONS: Superparamagnetic iron oxide nanoparticles; VEGF: Vascular endothelial growth factor.

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