Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for transcutaneous immunization

2021 ◽  
Vol 608 ◽  
pp. 125607
Author(s):  
Issei Takeuchi ◽  
Takaaki Suzuki ◽  
Kimiko Makino
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles ◽  
Transcutaneous Immunization

scholarly journals Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles

2012 ◽  
Vol 163 (2) ◽  
pp. 230-239 ◽  
Author(s):  
Amit Kumar ◽  
Piyanuch Wonganan ◽  
Michael A. Sandoval ◽  
Xinran Li ◽  
Saijie Zhu ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Plga Nanoparticles ◽  
Transcutaneous Immunization

Transdermal delivery of estradiol-loaded PLGA nanoparticles using iontophoresis for treatment of osteoporosis

2016 ◽  
Vol 27 (5) ◽  
pp. 475-483 ◽  
Author(s):  
Issei Takeuchi ◽  
Kohta Fukuda ◽  
Shiori Kobayashi ◽  
Kimiko Makino
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles ◽  
Treatment Of Osteoporosis

Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo

2012 ◽  
Vol 92 ◽  
pp. 50-54 ◽  
Author(s):  
Keishiro Tomoda ◽  
Hiroto Terashima ◽  
Kenichi Suzuki ◽  
Toshio Inagi ◽  
Hiroshi Terada ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles

Hydrophilic drug-loaded PLGA nanoparticles for transdermal delivery

2017 ◽  
Vol 295 (6) ◽  
pp. 977-983 ◽  
Author(s):  
Issei Takeuchi ◽  
Keishiro Tomoda ◽  
Megumi Koji ◽  
Kimiko Makino
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles ◽  
Hydrophilic Drug

Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for positively charged drugs

2017 ◽  
Vol 160 ◽  
pp. 520-526 ◽  
Author(s):  
Issei Takeuchi ◽  
Tomoyoshi Takeshita ◽  
Takaaki Suzuki ◽  
Kimiko Makino
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles ◽  
Positively Charged

Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis

2011 ◽  
Vol 88 (2) ◽  
pp. 706-710 ◽  
Author(s):  
Keishiro Tomoda ◽  
Hiroto Terashima ◽  
Kenichi Suzuki ◽  
Toshio Inagi ◽  
Hiroshi Terada ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Plga Nanoparticles

scholarly journals Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia

2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Woo Yeup Jeong ◽  
Sodam Kim ◽  
So Yun Lee ◽  
Hyeseon Lee ◽  
Dong Wook Han ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Plga Nanoparticles ◽  
Follicle Cells ◽  
Common Disease ◽  
Solvent Evaporation Method ◽  
The World ◽  
Low Efficiency ◽  
Permeation Test

Abstract Background Alopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects. Method MXD and Rhodamine B (Rho B) are encapsulated in poly(Lactide-co-Glycolide) grafted hyaluronate nanoparticles (HA-PLGA/MXD NPs, HA-PLGA/Rho B NPs) which is prepared with W/O/W solvent evaporation method. After then, the investigation is carried out to confirm the feasibility of NPs in alopecia treatment. Results Both of HA-PLGA/MXD NPs and HA-PLGA/Rho B NPs are successfully prepared. In addition, it is confirmed that HA-PLGA NPs sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test. Conclusion Taken together, HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop the efficient and effective platform of transdermal drug delivery for the treatment of various diseases.

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