Microencapsulation of bovine hemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique

2004 ◽  
Vol 33 (3-4) ◽  
pp. 177-183 ◽  
Author(s):  
F.T Meng ◽  
G.H Ma ◽  
Y.D Liu ◽  
W Qiu ◽  
Z.G Su
Keyword(s):  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Bovine Hemoglobin ◽  
Emulsion Technique ◽  
High Entrapment Efficiency

scholarly journals PREPARATION, CHARACTERIZATION AND EVALUATION OF POLY (LACTIDE –CO –GLYCOLIDE) MICROSPHERES FOR THE CONTROLLED RELEASE OF ZIDOVUDINE

2017 ◽  
Vol 9 (12) ◽  
pp. 70 ◽  
Author(s):  
Seema Kohli ◽  
Abhisek Pal ◽  
Suchit Jain
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Average Particle ◽  
Plga Microspheres ◽  
Good Reproducibility ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

Objective: The purpose of this research work was to develop and evaluate microspheres appropriate for controlled release of zidovudine (AZT).Methods: The AZT loaded polylactide-co-glycolide (PLGA) microspheres were prepared by W/O/O double emulsion solvent diffusion method. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). The influence of formulation factors (drug: polymer ratio, stirring speed, the concentration of surfactant) on particle size encapsulation efficiency and in vitro release characteristics of the microspheres was investigated. Release kinetics was studied and stability study was performed as per ICH guidelines.Results: Scanning electron microscopy (SEM) images show good reproducibility of microspheres from different batches. The average particle size was in the range of 216-306 μm. The drug-loaded microspheres showed 74.42±5.08% entrapment efficiency. The cumulative percentage released in phosphate Buffer solution (PBS) buffer was found to be 55.32±5.89 to 74.42±5.08 %. The highest regressions (0.981) were obtained for zero order kinetics followed by Higuchi (0.968) and first order (0.803).Conclusion: Microsphere prepared by double emulsion solvent diffusion method was investigated and the results revealed that 216-306 μm microsphere was successfully encapsulated in a polymer. FT-IR analysis, entrapment efficiency and SEM Studies revealed the good reproducibility from batch to batch. The microspheres were of an appropriate size and suitable for oral administration. Thus the current investigation show promising results of PLGA microspheres as a matrix for drug delivery and merit for In vivo studies for scale up the technology.

Study of the Effect of Formulation Parameters/Variables to Control the Nanoencapsulation of Hydrophilic Drug via Double Emulsion Technique

2011 ◽  
Vol 7 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Mohamed Ayoub ◽  
Naveed Ahmed ◽  
Nader Kalaji ◽  
Catherine Charcosset ◽  
Ayoub Magdy ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Emulsion Technique ◽  
Hydrophilic Drug ◽  
Formulation Parameters

Preparation And Characterization Of Acyclovir Nanoparticles By Double Emulsion Technique

2007 ◽  
Vol 23 (1) ◽  
Author(s):  
A O Kamel ◽  
G A Awad ◽  
A S Geneidi ◽  
N D Mortada ◽  
N D Mortada
Keyword(s):  
Double Emulsion ◽  
Emulsion Technique

Optimized Formulation of Colon Targeted Microsheres for Prednisolone Sodium Phosphate: Application of Taguchi Experimental Design

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Kanchan Sonker ◽  
Randhir Gupta ◽  
Jovita Kanoujia ◽  
Viney Chawla ◽  
Manisha Pandey ◽  
...  
Keyword(s):  
Experimental Design ◽  
Sodium Phosphate ◽  
Double Emulsion ◽  
Statistical Design ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Taguchi Experimental Design ◽  
Emulsion Solvent Diffusion Method ◽  
Polymer Ratio

Microspheres of ethyl cellulose containing prednisolone sodium phosphate were prepared by double emulsion solvent diffusion method. A statistical design was used to study and optimize the variables that affect the preparation of microspheres. The experimental results showed that the drug: polymer ratio, stirring speed, concentration of surfactant, and volume of processing media played an important role in the formulation of microspheres. The prepared microspheres were characterized on the basis of particle size, scanning electron microscopy, entrapment efficiency and <italic>in vitro</italic> release. Taguchi experimental design helped to reduce the number of experiments. Optimized formulation exhibited Higuchi square root kinetics displaying diffusion from the microspheres as the main mechanism for drug release.

Construction of novel pH-sensitive hybrid micelles for enhanced extracellular stability and rapid intracellular drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (107) ◽  
pp. 105957-105968 ◽  
Author(s):  
Shaoping Yin ◽  
Liang Chang ◽  
Tie Li ◽  
Guangji Wang ◽  
Xiaochen Gu ◽  
...  
Keyword(s):  
Drug Release ◽  
Entrapment Efficiency ◽  
Ph Sensitive ◽  
High Entrapment Efficiency ◽  
Premature Release

Novel pH-sensitive hybrid micelles with high entrapment efficiency were constructed to realize rapid intracellular drug release without premature release.

scholarly journals Formulation And Evaluation Of Floating Microspheres Of Cefdinir

2021 ◽  
Vol 23 (11) ◽  
pp. 906-929
Author(s):  
Jeslin. D ◽  
◽  
Nithya Kalyani.K ◽  
Padmaja. V ◽  
Suresh Kumar.P ◽  
...  
Keyword(s):  
Drug Release ◽  
Residence Time ◽  
Entrapment Efficiency ◽  
Sustained Drug Release ◽  
Magnetic Systems ◽  
Gastric Residence Time ◽  
Gum Karaya ◽  
High Entrapment Efficiency ◽  
Full Factorial ◽  
Good Flow

Various approaches have been used to retain the dosage form in the stomach as a way ofincreasing the gastric residence time (GRT), including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible, or swellable systems; andsuperporous hydrogel systems. The aim of this study was to prepare and evaluate floatingmicrospheres of cefdinir for the prolongation of gastric residence time. Themicrospheres were prepared byCapillary Extrusion method.A full factorial design was applied to optimize the formulation. The optimum batch of microsphere exhibited smooth surfaces with good flow and packing properties, prolonged sustained drug release, remained buoyant for more than 12 hrs, high entrapment efficiency upto68%.Scanning electron microscopy confirmed the hollown structure with particle size in the order of190 μm. The studies revealed that increase in concentration of gum Karaya increased the drug release from the floating microspheres.

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