FORMULATION AND EVALUATION OF THYROID HORMONE (T4) IMMEDIATE RELEASE TABLETS

The aim of this research work is to formulate and evaluate Levothroxine sodium immediate release tablets prepared by direct compression method . Five formulations were evaluated for different pre and post compression parameter and in vitro drug release studies.The results of pre compression parameters of formluation 1 to 5 were compared with prescribed limits. It showed that formulation 1 to 5 powder blend exhibit good flow property and compressibility property. The disintegration time of all formulation was found to be in the range 2mins 09 secsto 4mins 03 secs.Thus, based on evaluation of different parameters it was concluded that formulation of immediate release tablet Levothyroxine sodium was successfully done and F-5 showed almost 93% drug release at 45 mins in Alkaline borate buffer( pH 10). Keywords: Thyroid hormone (T4), Immediate release tablets, Direct compression, Dissolution.

Chihuahua-Sacramento and tabalaopa-aldama aquifers of Chihuahua state, Mexico: linkage and importance of geostatistical and hydrogeochemical analysis

The objective of this study is to gather sufficient information to make a diagnosis of drinking water sufficiency in the Chihuahua-Sacramento and Tabalaopa-Aldama aquifers. By applying advanced statistical techniques, the goal is to find the variables that control the regional and intermediate flow systems and establish the characteristics of a heterogeneous aquifer. The variables chosen from those established were as follows: total solids (TS), nitrates (NO3), fluoride (F), and total hardness, among others. In order to establish a conceptual model, the results from all the sampling were carried out by the National Water Commission (CONAGUA) in the aforementioned aquifers and were used to obtain an approximate flow differentiation. The results showed a good flow differentiation. In addition, a group of mixed water was detected among the intermediate and regional flows. The increase in the average regional flow values suggests a rise in the incidence of an upward flow of the regional flow as a result of uncontrolled extraction.

Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide

The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.

Formulation And Evaluation Of Floating Microspheres Of Cefdinir

Various approaches have been used to retain the dosage form in the stomach as a way ofincreasing the gastric residence time (GRT), including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible, or swellable systems; andsuperporous hydrogel systems. The aim of this study was to prepare and evaluate floatingmicrospheres of cefdinir for the prolongation of gastric residence time. Themicrospheres were prepared byCapillary Extrusion method.A full factorial design was applied to optimize the formulation. The optimum batch of microsphere exhibited smooth surfaces with good flow and packing properties, prolonged sustained drug release, remained buoyant for more than 12 hrs, high entrapment efficiency upto68%.Scanning electron microscopy confirmed the hollown structure with particle size in the order of190 μm. The studies revealed that increase in concentration of gum Karaya increased the drug release from the floating microspheres.

Natural Language Processing Applied to Reduction of False and Missed Alarms in Kick and Lost Circulation Detection

Kick and lost circulation events are large contributors to non-productive time. Therefore, early detection of these events is crucial. In the absence of good flow in and flow out sensors, pit volume trends offer the best possibility for influx/loss detection, but errors occur since external mud addition /removal to the pits is not monitored or sensed. The goal is to reduce false alarms caused by such mud additions and removal. Data analyzed from over 100s of wells in North America show that mud addition and removal results in certain unique pit volume gain / loss trends, and these trends are quite different from a kick, a lost circulation or a wellbore breathing event trend. Additionally, driller's input text memos into the data aggregation system (EDR) and these memos often provide information with regards to pit operations. In this paper, we introduce a method that utilizes a Bayesian network to aggregate trends detected in time-series data with events identified by natural language processing (NLP) of driller memos critical to greatly improve the accuracy and robustness of kick and lost circulation detection. The methodology was implemented in software that is currently running on rigs in North America. During the test phase, we applied it on several historical wells with lost circulation events and several historical wells with kick events. We were able to identify and quantify the losses even during connections and mud additions, where usually pit volume was increasing despite continual losses. Also, the real-time simultaneous analysis of driller memos provides context to pit volume trends and further reduce the false alarms. The algorithm is also able to take account of pit volume that was reduced due to drilling. Quantification of the losses offers more insight into what lost circulation material to use and the changes in the rate of loss while drilling. This approach was very robust in discovering kicks as well and differentiating it from mud removal and wellbore breathing events. These historical case studies will be detailed in this paper. This is the first time that patterns in mud volume addition and removal detected from time-series data have been used along with driller memos using NLP to reduce false alerts in kick and lost circulation detection. This approach is particularly useful in identifying kick and lost circulation events from pit volume data, especially when good flow in and flow out sensors are not available. The paper provides guidance on how real-time sensor data can be combined with textual data to improve the outputs from an advisory system.

Preliminary Characterization of Co-processed Excipients of Okra (Abelmoschus esculentus) Mucilage and Pregelatinized Potato Starch

Background: Okra mucilage is highly viscous with good binding properties in tablets. Pregelatinized starches have significantly improved flow properties but produce tablets of poor mechanical strength.Objective: Preliminary evaluation of co-processed excipients of Okra mucilage and pregelatinized potato starch as directly-compressible excipients.Methods: Polymers were characterized for morphology (SEM), crystallinity (FT-IR) and flow properties. Coprocessed excipients were developed with Okra mucilage and pregelatinized potato starch at different ratios of starch: mucilage (95:5, 90:10, 85:15, 80:20, 70:30), using the co-fusion method. The flow, packing and compaction properties of the co-processed excipients were evaluated using density measurements, angle of repose, angle of internal friction, Kawakita model, consolidation index (C) and consolidation rate (K).Results: Larger agglomerates of the co-processed excipients indicated formation of a new polymer. FT-IR spectra showed retention of all the major peaks of individual polymers. Okra mucilage imparted swelling while starch improved flow in the co-processed excipients (Hausner’s ratio 1.12-1.20). Values from Kawakita plots revealedcohesiveness and compressibility were imparted to the co-processed excipients (a = 0.300–0.329; b = 0.078–0.361) suggesting good compactibility. Consolidation index and rate were observed to increase with Okra mucilage content, implying improved rate of packing as well as enhanced flow (C = 0.566-1.389; K = 0.123-0.424). The batch containing starch: mucilage 70:30 gave the best properties of good flow, cohesiveness and compactibility, essential parameters required in directly-compressible excipients.Conclusion: The co-processed excipients of Okra mucilage and pregelatinized potato starch could therefore be used as excipients for direct compression in tablet formulations.

Extraction and Evaluation of Lepidium Sativum and Flax Seeds Mucilage as a Pharmaceutical Granulation Binder

The powders holdtogether by a binder to form granule. Some excipients of natural origins arecurrently available as an alternative over the synthetic ones in pharmaceuticalformulation. The aim of this study was to isolate the mucilage from differentplant seeds and compare them to evaluate the binding effects. In present studyan effort was made to investigate the efficacy of mucilage obtained from Lepidiumsativum and flax seeds as granules excipient. The mucilage   was extracted from selected seeds byconventional method by precipitation of soaked and blended seeds in acetone.The dried mucilages were subjected to several phytochemical and physicochemicalproperties. Granules were formulated by wet granulation method by usingextracted mucilage as a binding agent and comparison was made against thegranules prepared with standard binder as PVP. The granules evaluated byvarious physical properties such as (bulk and tapped densities, Hausner’sratio, Carr’s index, angle of repose and friability). The results showed thatthe granules prepared from extracted mucilage as a binder had good flow andmechanical properties, all evaluated parameters were within the permissiblelimits. Thus, mucilage could be used as an alternative binding agent in pharmaceuticalgranules.

Effect of Precursor Design on Preparing Open-Cell Aluminum Foam Fabricated by Space-Holder Method

Open-cell aluminum foams with spherical cells have great potential application due to their reliable structural and functional performance. However, a problem of poor cell connectivity always arises during fabrication. Three precursor designs were explored to optimize the cell structure. The results showed that the lack of the treatment of the space holders caused poor cell connectivity and a lower porosity, which could be resolved by introducing alcohol as a binder or hot-pressing space holders in precursor designs. Nevertheless, a poor fluid of the granules in the former had a negative effect on porosity improvement, whereas the latter created a precursor with strong bonding between the granules with good flow characteristics and led to a significant improvement in cell connectivity and porosity. This work could provide an approach to designing precursor structures in order to tailor the structure of the final open-cell aluminum foam.

876 A Sweeping Success – Management of Type 1A Endoleak Using A Chimney Graft Technique

Endoleak is a recognised complication after Endovascular Abdominal Aortic Aneurysm Repair (EVAR). In the setting of a rapidly expanding aneurysm – time is of the essence. Perfusion of the renal arteries, superior mesenteric artery (SMA) and coeliac artery must be maintained. To facilitate this a customised fenestrated endograft may be used or a chimney endovascular aortic repair (CHEVAR). A 78-year-old female initially underwent EVAR in 2016 for a ruptured 6.9cm AAA. She made a good recovery at that time. She was enlisted in a surveillance programme. Her most recent duplex showed an aneurysmal sac of 10cm with associated type 1A endoleak. Given these findings waiting for a fenestrated graft posed an unacceptable delay. She underwent a CHEVAR with bilateral axillary and right femoral access. She had chimney stents deployed in the renal arteries and SMA with aortic cuff extension proximally. Her completion angiogram showed good proximal seal with patent stents. She was unexpectedly unstable post-operatively and had a CT scan which revealed a re-ruptured aneurysm. She was treated in ICU and recovered well. Repeat imaging showed good flow in all 4 grafts with no endoleak. This case demonstrates the challenges of managing endoleak post EVAR and the importance of robust surveillance and appropriate, timely treatment.

CELLULOSE ACETATE FLOATING MICROSPHERES OF METFORMIN HYDROCHLORIDE: FORMULATION AND CHARACTERIZATION

In this study, floating microspheres of metformin hydrochloride were prepared by using cellulose acetate polymer by solvent evaporation method. Four formulations were prepared by varying the ratio of drug and polymer. The prepared microspheres were then subjected to various evaluation parameters such as drug content, micromeritic evaluations, FTIR, SEM, floatability and in vitro dissolution study. Formulation F1 (1:1 ratio of polymer and drug) showed the highest drug release and drug content with good flow properties. The cumulative percentage of drug release significantly decreased with decreasing drug concentration with a constant polymer ratio. Scanning Electron Microscopy images of all formulations showed that the prepared floating microspheres were irregular in shape, and the surface was found to be non- uniform and rough. In vitro release studies indicated the mechanism of the drug release to follow the Korsemeyer-Peppas model, and “n” value was found to be between 0.54-1.89, indicating anomalous transport mechanism.