Sustainable release of nerve growth factor for peripheral nerve regeneration using nerve conduits laden with Bioconjugated hyaluronic acid-chitosan hydrogel

2021 ◽  
pp. 109509
Author(s):  
Haixing Xu ◽  
Yi Yu ◽  
Lingxi Zhang ◽  
Furong Zheng ◽  
Yixia Yin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Chitosan Hydrogel ◽  
Nerve Growth ◽  
Nerve Conduits

Preparation and characterization of injectable chitosan–hyaluronic acid hydrogels for nerve growth factor sustained release

2016 ◽  
Vol 32 (2) ◽  
pp. 146-162 ◽  
Author(s):  
Haixing Xu ◽  
Lingxi Zhang ◽  
Yun Bao ◽  
Xiumei Yan ◽  
Yixia Yin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Sustained Release ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth ◽  
Nerve Conduits ◽  
Hyaluronic Acid Hydrogel

The usage of hollow nerve conduits shows inferior recovery effect on the repair of peripheral nerve defects. In this study, a biocompatible and biodegradable pH-induced injectable chitosan–hyaluronic acid hydrogel for nerve growth factor encapsulation and sustained release was developed as the fillers in the lumen of hollow nerve conduit to reform its microenvironment for peripheral nerve regeneration. The physicochemical properties of hydrogel were characterized by gelation time, Fourier transform infrared spectroscopy, scanning electron microscopy, compressive modulus, porosity, swelling ratio, and in vitro degradation. The in vitro nerve growth factor release profiles and cell evaluation were also investigated. The results show that the structure of chitosan–hyaluronic acid hydrogel is composed of interconnected channels with a controllable pore diameter ranging from 20 to 100 µm. The hydrogel can be degraded more than 70% within 8 weeks in vitro and is available for nerve growth factor sustained release. The chitosan–hyaluronic acid/nerve growth factor hydrogel is non-toxic and suitable for adhesion and proliferation of nerve cells and capable of maintaining nerve growth factor activity. Therefore, it could be a promising intraluminal filler of nerve conduits for peripheral nerve regeneration in neural tissue engineering.

scholarly journals Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor

2015 ◽  
Vol 23 (3) ◽  
pp. 423-433 ◽  
Author(s):  
Shiying Li ◽  
Xinghui Wang ◽  
Yun Gu ◽  
Chu Chen ◽  
Yaxian Wang ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth

Beneficial effect of nerve growth factor-7S on peripheral nerve regeneration through inside-out vein grafts: An experimental study

Microsurgery ◽  
2004 ◽  
Vol 24 (5) ◽  
pp. 408-415 ◽  
Author(s):  
Andreas I. Gravvanis ◽  
Dimosthenis A. Tsoutsos ◽  
George A. Tagaris ◽  
Apostolos E. Papalois ◽  
Charalampos G. Patralexis ◽  
...  
Keyword(s):  
Experimental Study ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Beneficial Effect ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth ◽  
Vein Grafts ◽  
Inside Out
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