This study presents an investigation into high-temperature resistance of alkali-activated slag concrete (AASC). Sodium oxide (Na2O) concentrations of 4%, 5% and 6% of slag weight and liquid sodium silicate (SiO2) with modulus ratio of 0.8 ( mass ratio of SiO2 to Na2O ) were used as activators to activate granulated blast furnace slag (GBFS). All cylindrical specimens with the same binder content and liquid/binder ratio of 0.5 were cast and cured in the air, under the saturated limewater and in a curing room at relative humidity of 80% RH and temperature of 60 °C, respectively. Test results demonstrate that the high-temperature resistance of AASC decreased with an increase of temperature. The compressive strength and high-temperature resistance of AASC improved with an increase dosage of Na2O and AASC cured at relative humidity of 80% RH and temperature of 60 °C has the superior performance, followed the AASC by air curing and saturated limewater curing. The higher compressive strength and superior high-temperature resistance have been obtained in AASC than comparable OPC.