Sublingual versus vaginal misoprostol (400 μg) for cervical priming in first-trimester abortion: a randomized trial

Background: To compare the effectiveness, side effects, and patient satisfaction of buccal versus vaginal misoprostol administration in first trimester abortions.Methods: Women opting for first trimester abortion received oral Mifepristone followed 48 hours latermisoprostol. Group A received Misoprostol via buccal route whereas group B received Misoprostol vaginally. A comparative analysis using SPSS was done.Results: Giving 800µg Misoprostol by either buccal or vaginal route after oral Mifepristone have comparable efficacy in terms of complete abortion rate (96% in buccal group versus 98% in vaginal group; p value = 0.495), failure rate being statistically similar (4% versus 2%). Drug abortion interval was comparable in the two groups. (11.16 hour in buccal group and 12.32 hours in vaginal group). Few side effects like nausea and vomiting, shivering, diarrohea was significantly higher with vaginal Misoprostol while abdominal cramps, altered taste were found more with the buccal group.Conclusions: Buccal Misoprostol is comfortable and easier to administer when compared to other routes and it has potential to be developed as a self-administered regimen. Buccal Misoprostol is as efficacious as vaginal Misoprostol with significantly lesser side effects up to 7 weeks of period of gestation.

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Second trimester abortion by laminaria followed by vaginal misoprostol or intrauterine prostaglandin F2α: a randomized trial

Contraception ◽

10.1016/s0010-7824(02)00291-3 ◽

2002 ◽

Vol 65 (6) ◽

pp. 411-413 ◽

Cited By ~ 7

Author(s):

B Paz ◽

G Ohel ◽

T Tal ◽

S Degani ◽

E Sabo ◽

...

Keyword(s):

Randomized Trial ◽

Prostaglandin F2α ◽

Second Trimester ◽

Trimester Abortion ◽

Second Trimester Abortion ◽

Vaginal Misoprostol

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The effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester abortion: a double-blind, randomized study

The European Journal of Contraception & Reproductive Health Care ◽

10.1080/ejc.8.4.197.202 ◽

2003 ◽

Vol 8 (4) ◽

pp. 197-202 ◽

Cited By ~ 6

Author(s):

M. M. Inal ◽

K. Ertopçu ◽

A. Arici ◽

I. Özelmas

Keyword(s):

Randomized Study ◽

First Trimester ◽

Cervical Dilatation ◽

Double Blind ◽

Trimester Abortion ◽

Vaginal Misoprostol

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First trimester abortion with mifepristone and vaginal misoprostol

Contraception ◽

10.1016/s0010-7824(01)00196-2 ◽

2001 ◽

Vol 63 (5) ◽

pp. 247-250 ◽

Cited By ~ 26

Author(s):

Ulla Breth Knudsen

Keyword(s):

First Trimester ◽

Trimester Abortion ◽

Vaginal Misoprostol

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Vaginal misoprostol before first trimester abortion

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(97)00227-0 ◽

1998 ◽

Vol 60 (2) ◽

pp. 175-176 ◽

Cited By ~ 4

Author(s):

E.R Wiebe ◽

M.J Rawling

Keyword(s):

First Trimester ◽

Trimester Abortion ◽

Vaginal Misoprostol

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Efficacy of combination of oral mifepristone and vaginal misoprostol in termination of pregnancy up to 63 days of gestation

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195350 ◽

2019 ◽

Vol 8 (12) ◽

pp. 4951

Author(s):

Shivani Gupta

Keyword(s):

First Trimester ◽

Termination Of Pregnancy ◽

Trimester Abortion ◽

Safe Alternative ◽

Patient Counselling ◽

Women Health ◽

Medical Termination Of Pregnancy ◽

Medical Termination ◽

Vaginal Misoprostol

Background: Unsafe and illegal abortions are one of the major problems in women health in India. Despite legal approval for medical termination of pregnancy in 1971, unsafe abortion still remains the third leading cause of maternal deaths in the country, contributes eight percent of such deaths annually. The objective of this study was to study efficacy of Mifepristone 200 mg orally followed 36-48 hours later by Misoprostol 800 microgms per vaginally in women undergoing medical termination of early pregnancy (up to 63 days of gestational age).Methods: The present study included 60 pregnant women requesting termination of pregnancy in the first trimester. Women who fulfilled the inclusion criteria were included in the study. Women without medical or surgical contraindications to Mifepristone and Misoprostol were included. Patients with previous caesarean sections were also included.Results: In our study 60 women were included, majority were in age group 20-29 years of age and majority of cases were primipara or multipara. The success rate in terms of complete abortion was 97%, 2% needed surgical evacuation and 1% lost to follow up. Side effects were nausea, vomiting, diarrhoea, abdominal cramps, pyrexia etc. The method proved to be safe, effective, cheap, non-invasive and has minimal or no complications.Conclusions: Medical termination of pregnancy with oral mifepristone and vaginal misoprostol is an effective method for first trimester abortion. The prerequisite for the method is patient counselling, patient participation and willingness for regular follow up and to report any complication. Hence this method comes out to be a safe alternative to surgical method which is invasive and costly.

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