From mice to men: Murine models of colorectal cancer for use in translational research

2016 ◽  
Vol 98 ◽  
pp. 94-105 ◽  
Author(s):  
Jonathan P. Evans ◽  
Paul A. Sutton ◽  
Boleslaw K. Winiarski ◽  
Stephen W. Fenwick ◽  
Hassan Z. Malik ◽  
...  
2019 ◽  
Vol 233 ◽  
pp. 310-322
Author(s):  
Eleanor McCabe-Lankford ◽  
Margarita Peterson ◽  
Bryce McCarthy ◽  
April J. Brown ◽  
Brad Terry ◽  
...  

Author(s):  
Yue Wang Webster ◽  
Ernst R Dow ◽  
Mathew J Palakal

Even though numerous tools and technologies have been developed to meet this need with various degrees of success, a conceptual framework is needed to fully realize the value of those tools and technologies. The authors propose Complex System (CS) to be the logical foundation of such a framework. Since translational research is a spiral and dynamic process. With the CS mindset, they designed a multi-layer architecture called HyGen (Hypotheses Generation Framework) to address the challenges faced by translational researchers. In order to evaluate the framework, the authors carried out heuristic and quantitative tests in Colorectal Cancer disease area. The results demonstrate the potential of this hybrid approach to bridge silos and to identify hidden links among clinical observations, drugs, genes and diseases, which may eventually lead to the discovery of novel disease targets, biomarkers and therapies.


Author(s):  
Syed Sultan Beevi ◽  
Naveen Kumar Tangudu ◽  
Vinod Kumar Verma ◽  
Lekha Dinesh Kumar

2020 ◽  
Vol 21 (11) ◽  
pp. 4105
Author(s):  
Alessandro Passardi ◽  
Emanuela Scarpi ◽  
Paola Ulivi

Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world [...]


Chemotherapy ◽  
2005 ◽  
Vol 51 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Hideyuki Mishima ◽  
Takeshi Kato ◽  
Mieko Yanagisawa ◽  
Toshimasa Tsujinaka ◽  
Isamu Nishisho ◽  
...  

Author(s):  
Mariska Bierkens ◽  
Wim van der Linden ◽  
Ward Weistra ◽  
Kees van Bochove ◽  
Jeroen A.M. Beliën ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document