Acute coronary syndromes: Targeting the vulnerable atherosclerotic plaque – new approaches for stabilization and regression of the plaque

2008 ◽  
Vol 5 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Sivaram Pillarisetti ◽  
Uday Saxena
Keyword(s):  
Atherosclerotic Plaque ◽  
Acute Coronary Syndromes ◽  
Vulnerable Atherosclerotic Plaque ◽  
New Approaches ◽  
Coronary Syndromes

scholarly journals Black blood vessel wall MRI to identify vulnerable atherosclerotic plaque in a non-stenotic intracranial vertebral artery as a cause of acute ischaemia

2020 ◽  
Vol 6 (4) ◽  
pp. 20200061
Author(s):  
Sundip Dhanvant Udani ◽  
Pervinder Bhogal
Keyword(s):  
Vertebral Artery ◽  
Atherosclerotic Plaque ◽  
Vessel Wall ◽  
Black Blood ◽  
Vulnerable Atherosclerotic Plaque ◽  
Acute Ischaemia ◽  
Neurological Sequelae ◽  
Intracranial Atherosclerotic Disease ◽  
Coronary Syndromes ◽  
Neuroimaging Techniques

Conventional neuroimaging techniques for investigating the cause of stroke are mainly centred on investigating luminal stenosis. The pathophysiology of intracranial atherosclerotic disease (ICAD) and stroke is complex and extends beyond just vessel narrowing. The concept of the vulnerable atherosclerotic plaque, that can result in acute coronary syndromes, has been well described in the cardiac literature 1,2 although this concept is less well accepted among stroke physicians. We describe a case of a 61-year-old male with acute neurological sequelae from a non-stenotic atherosclerotic plaque of the intracranial vertebral artery. This case report describes the additional use of vessel wall MRI techniques to aid the radiologist in identifying such vulnerable lesions and therefore helping to tailor management and prevent further clinical deterioration.

scholarly journals Thrombosis, physical activity, and acute coronary syndromes

2011 ◽  
Vol 111 (2) ◽  
pp. 599-605 ◽  
Author(s):  
Arun Kumar ◽  
Subrata Kar ◽  
William P. Fay
Keyword(s):  
Physical Activity ◽  
Atherosclerotic Plaque ◽  
Clinical Studies ◽  
Acute Coronary Syndromes ◽  
Plaque Rupture ◽  
Thrombus Formation ◽  
Coagulation Cascade ◽  
Plaque Disruption ◽  
Coronary Syndromes ◽  
Atherosclerotic Plaque Rupture

Acute coronary syndromes (ACS) are common, life-threatening cardiac disorders that typically are triggered by rupture or erosion of an atherosclerotic plaque. Platelet deposition and activation of the blood coagulation cascade in response to plaque disruption lead to the formation of a platelet-fibrin thrombus, which can grow rapidly, obstruct coronary blood flow, and cause myocardial ischemia and/or infarction. Several clinical studies have examined the relationship between physical activity and ACS, and numerous preclinical and clinical studies have examined specific effects of sustained physical training and acute physical activity on atherosclerotic plaque rupture, platelet function, and formation and clearance of intravascular fibrin. This article reviews the available literature regarding the role of physical activity in determining the incidence of atherosclerotic plaque rupture and the pace and extent of thrombus formation after plaque rupture.

Atherosclerotic plaque in HIV-positive patients presenting with acute coronary syndromes

2019 ◽  
Vol 30 (4) ◽  
pp. 203-207
Author(s):  
Ahmed Vachiat ◽  
Keir McCutcheon ◽  
Nqoba Tsabedze ◽  
Don Zachariah ◽  
Pravin Manga
Keyword(s):  
Atherosclerotic Plaque ◽  
Acute Coronary Syndromes ◽  
Hiv Positive ◽  
Coronary Syndromes

scholarly journals Increasing specificity of high-sensitivity troponin: New approaches and perspectives in the diagnosis of acute coronary syndromes

2013 ◽  
Vol 62 (4) ◽  
pp. 205-209 ◽  
Author(s):  
Maria Giulia Marini ◽  
Maria Teresa Cardillo ◽  
Annalisa Caroli ◽  
Chiara Sonnino ◽  
Luigi M. Biasucci
Keyword(s):  
Acute Coronary Syndromes ◽  
High Sensitivity ◽  
New Approaches ◽  
High Sensitivity Troponin ◽  
Coronary Syndromes

scholarly journals Cocaine-Associated Myocardial Infarction: Should They All Be Stented?

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Sazzli Kasim ◽  
Ronan O'Donabhain ◽  
Eugene Mcfadden
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chest Pain ◽  
Platelet Activation ◽  
Atherosclerotic Plaque ◽  
Acute Coronary Syndromes ◽  
Plaque Rupture ◽  
Coronary Syndromes ◽  
Atherosclerotic Plaque Rupture ◽  
Catheterization Procedure

Cocaine use is a known cause of chest pain and acute myocardial infarction and frequently leads to cardiac catheterization procedure. The treatment of cocaine-related acute coronary syndromes presents unique challenges because a variety of mechanisms including atherosclerotic plaque rupture, platelet activation, and coronary vasospasm may contribute to the pathogenesis. Our case highlights important considerations taken in dealing with this acute scenario

ASSA13-01-5 Coronary Atherosclerotic Plaque Burden and Characteristics in Women with Acute Coronary Syndromes

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A2.1-A2
Author(s):  
Liu Chuanfen ◽  
Liu Jian ◽  
Wang Weimin ◽  
Lu Mingyu ◽  
Ma Yuliang ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Acute Coronary Syndromes ◽  
Plaque Burden ◽  
Coronary Atherosclerotic Plaque ◽  
Coronary Syndromes

scholarly journals New Approaches to the Role of Thrombin in Acute Coronary Syndromes: Quo Vadis Bivalirudin, a Direct Thrombin Inhibitor?

Molecules ◽  
2016 ◽  
Vol 21 (3) ◽  
pp. 284 ◽  
Author(s):  
María Esteve-Pastor ◽  
Diana Hernández-Romero ◽  
Mariano Valdés ◽  
Francisco Marín
Keyword(s):  
Acute Coronary Syndromes ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
New Approaches ◽  
Coronary Syndromes ◽  
Quo Vadis
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