A mechanochemical mechanism couples exocrine secretion to endocytic membrane retrieval

2021 ◽  
Vol 56 (11) ◽  
pp. 1557-1559
Author(s):  
Volker Haucke
Keyword(s):  
Exocrine Secretion

Secretin-induced exocrine secretion in perfused pancreas isolated from diabetic rats

Diabetes ◽  
1988 ◽  
Vol 37 (9) ◽  
pp. 1173-1180 ◽  
Author(s):  
Y. Okabayashi ◽  
M. Otsuki ◽  
A. Ohki ◽  
T. Nakamura ◽  
S. Tani ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Diabetic Rats ◽  
Perfused Pancreas

scholarly journals Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion

2021 ◽  
Vol 56 (11) ◽  
pp. 1603-1616.e6
Author(s):  
Kumari Kamalesh ◽  
Nadav Scher ◽  
Tom Biton ◽  
Eyal D. Schejter ◽  
Ben-Zion Shilo ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Exocrine Secretion

scholarly journals beta-Adrenergic regulation of protein phosphorylation and its relationship to exocrine secretion in dispersed rat parotid gland acinar cells.

1981 ◽  
Vol 256 (18) ◽  
pp. 9731-9736 ◽  
Author(s):  
B.J. Baum ◽  
J.M. Freiberg ◽  
H. Ito ◽  
G.S. Roth ◽  
C.R. Filburn
Keyword(s):  
Parotid Gland ◽  
Protein Phosphorylation ◽  
Acinar Cells ◽  
Exocrine Secretion ◽  
Beta Adrenergic ◽  
Adrenergic Regulation ◽  
Rat Parotid Gland ◽  
Rat Parotid

Pancreatic exocrine secretion in anesthetized and conscious rats.

1977 ◽  
Vol 233 (6) ◽  
pp. E530 ◽  
Author(s):  
H Petersen ◽  
M I Grossman
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Pancreatic Exocrine

Both M1 and M3 receptors regulate exocrine secretion by mucous acini

1996 ◽  
Vol 271 (6) ◽  
pp. C1963-C1972 ◽  
Author(s):  
D. J. Culp ◽  
W. Luo ◽  
L. A. Richardson ◽  
G. E. Watson ◽  
L. R. Latchney
Keyword(s):  
Inhibitory Effect ◽  
Exocrine Secretion ◽  
Muscarinic Agonist ◽  
High Affinity ◽  
Muscarinic Response ◽  
M1 Receptor ◽  
M3 Receptors ◽  
Pharmacological Studies ◽  
Equilibrium Dissociation

We investigated the role of M1 and M3 receptors in regulating exocrine secretion from acini isolated from rat sublingual glands. In secretion experiments, we derived affinity values (KB) from Schild regression analysis for the antagonists pirenzepine (61.0 nM) and 4-diphenylacetoxy-N-methylpiperidine (4-DAMP; 1.06 nM). The KB for 4-DAMP is similar to its affinity value [equilibrium dissociation constant from competition studies (Ki); 1.81 nM] determined from radioligand competition experiments. In contrast, the KB for pirenzepine is between its high-affinity (17.6 nM) and low-affinity (404 nM) Ki values. In separate secretion experiments, we found that the M1 receptor antagonist, M1-toxin, induces a rightward shift in the concentration-response curve to muscarinic agonist and inhibits maximal secretion by 40%. The inhibitory effect of M1-toxin appears specific for M1 receptor blockade, since the toxin abolishes acinar high-affinity pirenzepine-binding sites and does not inhibit secretion induced by nonmuscarinic agents. Additional pharmacological studies indicate muscarinic receptors do not function through putative neural elements within isolated acini. Our combined results are consistent with both M1 and M3 receptors directly regulating mucous acinar exocrine secretion and indicate M3 receptors alone are insufficient to induce a maximal muscarinic response.

The effect of AFMK (N 1 -acetyl-N 2 -formyl-5-methoxykynuramine) on pancreatic exocrine secretion in the rats

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S28
Author(s):  
Katarzyna Nawrot-Porabka ◽  
Anna Leja-Szpak ◽  
Joanna Szklarczyk ◽  
Joanna Bonior ◽  
Marta Góralska ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Effect of Ethanol Intake on Pancreatic Exocrine Secretion in Mice

1992 ◽  
Vol 27 (9) ◽  
pp. 783-786 ◽  
Author(s):  
M. I. Vaccaro ◽  
O. M. Tiscornia ◽  
E. L. Calvo ◽  
M. A. Cresta ◽  
D. Celener
Keyword(s):  
Exocrine Secretion ◽  
Ethanol Intake ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Sow milk feeding vs. pancreatic exocrine secretion in pigs

1997 ◽  
Vol 50 (1-2) ◽  
pp. 151-152 ◽  
Author(s):  
S.G. Pierzynowski ◽  
B.R. Weström ◽  
B.W. Karlsson
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine ◽  
Milk Feeding

Immunohistochemical Study of Intralaryngeal Ganglia in the Cat

1992 ◽  
Vol 106 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Kuniyoshi Tsuda ◽  
Takemoto Shin ◽  
Sadahiko Masuko
Keyword(s):  
Neuronal Cell ◽  
Superior Laryngeal Nerve ◽  
Exocrine Secretion ◽  
Nerve Fibers ◽  
Neuronal Cell Bodies ◽  
Calcitonin Gene ◽  
Dense Distribution ◽  
Recurrent Laryngeal Nerves ◽  
Immunohistochemical Techniques ◽  
Almost All

To study the mechanism of autonomic regulation in the larynx, intralaryngeal local ganglia of the cat were investigated using immunohistochemical techniques. Small intralaryngeal ganglia were found in the peripheral portions of internal branches of the superior laryngeal nerve. Ninety-one percent of the ganglionic neurons were immunoreactive (IR) to vasoactive intestinal polypeptide (VIP), and 10% of the VIP-IR cells were also immunoreactive to enkephalin (ENK) and/or substance P (SP). The immunoreactivity of neuronal cell bodies remained unchanged even after denervation of the bilateral superior and recurrent laryngeal nerves. A dense distribution of calcitonin gene-related peptide (CGRP)-IR nerve fibers was found around almost all neuronal cells in the intralaryngeal. ganglia. A few VIP-IR, ENK-IR, and SP-IR nerve fibers were also observed. Only the CGRP-IR fibers disappeared after the denervation experiments. in the laryngeal glands and mucosal arterioles, VIP-IR nerve terminals were found that were also immunoreactive to ENK and/or SP. However, these Immunoreactive nerve endings in the glands and arterioles remained after the denervation experiments. The results of our study indicate that laryngeal exocrine secretion and blood flow are regulated by postganglionic autonomic parasympathetic fibers from intralaryngeal ganglia that contain VIP alone or VIP with ENK and/or SP, and that these ganglionic neurons may be innervated by CGRP-IR extrinsic nerve fibers.

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